To ensure that PHLDB3 is an optimal drug target, Lu says the next step is to further validate the cancer - causing role of PHLDB3 by
using mouse model systems either dependently or independently of p53.
I am currently working with Zika virus and how it affects the T cell response and T cell signaling through tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in
specific mouse model systems.
«When we ablated the function of either of these proteins in the skin of
a mouse model system it had no obvious effect.
«We have demonstrated the significance of this link in
a mouse model system, based on the use of a miR - 34a - deficient mouse strain that we had generated.
Researchers identified Cd14 in a genetic screen in
a mouse model system for IBD.
He is utilizing Drosophila and
mouse model system to understand the above mechanisms.
The advantage of the method, compared to targeted mutation experiments in
the mouse model system, is cost - efficient gene knock - out in large scale.