Sentences with phrase «mouse models»

In mouse models of Alzheimer's, they have already seen positive effects, he says.

The scientists, including Florian Reisinger from the Institute of Virology (HMGU) and Dr. Kristian Unger from the Research Unit Radiation Cytogenetics (HMGU) showed this using mouse models.

This new combination of electronics and drugs to intervene in an individual brain circuit might be used to create mouse models of other mood disorders for other studies, Dzirasa said.

Realizing they might have a potentially effective drug on their hands, Bogyo and his colleagues brought in Sonnenburg, whose lab is adept at using mouse models of C. difficile infection.

«This research project is a prime example of how mouse models can help us to better understand cancer diseases in human beings,» says Sabine Harlander.

The suppression of PPAR - γ and GLUT - 1 levels in mouse models of bacterial meningitis caused extensive neurological effects.

Wang said the researchers are now trying to find the human equivalent (orthologue) of the MMC9 cells they found in their mouse models.

Studies in mouse models suggest that BL - 9020 can inhibit beta cell death in the pancreas, thus preventing full maturation of Type 1 diabetes.

This is where we as basic scientists are coming in to see if we can use mouse models to learn this, because mice are very much like humans.»

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

What's more, the researchers found that blocking this mechanism with HCQ — a drug used to treat malaria that has been shown in previous studies to block autophagy — limited BRAF inhibitor - induced autophagy and enhanced cancer cell death in mouse models.

The research of different types of cancer and the testing of new treatments depends on accurate mouse models.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

The team led by Li and Chen generated three mouse models by deleting Cbf - beta at various stages of the osteoblast lineage.

The mouse models of autism on a normal lab diet (with a medium glycemic index) are already known to generate fewer new neurons, and some of their existing cells and neuronal connections are abnormal compared with those of normal mice.

For Chen and Birsoy, the next step in this line of research is to test the effects of ATPIF1 suppression in mouse models of mitochondrial dysfunction.

The patch, which feels like a mosquito bite when applied, has already proved effective in mouse models with type 1 diabetes for up to 9 hours, scientists report online before print in the Proceedings of the National Academy of Sciences.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

Scientists previously had to rely on less accurate mouse models.

In a paper published in Nature Immunology in 2011, Dr. Rostami and colleagues showed that the Th - 17 cells also produced another cytokine called GM - CSF, which created a chain reaction with another cell type ultimately increasing the GM - CSF levels in the brain of mouse models significantly.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

Franco is also collaborating with a researcher who came to his lab seeking help in refining his mouse models for diabetes.

«There have been many knockout mouse models of cleft palate, but very few of cleft lip, which is actually the more common defect in humans,» Carstens said.

Using mouse models Dr Grainger and his team looked at how and where monocytes are programs in response to toxoplasmosis, an infection caused by a common parasite called Toxoplasma gondii.

The researchers who study these various mouse models acknowledge that they differ from humans in many critical ways.

Yet he stresses that these mouse models give insights into pathogenesis and will allow for high - throughput screening of drugs and vaccines against the virus.

«For example, cancer research is heavily reliant on mouse models, and as a result we've become very good at curing mice, but that hasn't translated very well to humans.

The common pathway found in mouse models was also found in human tumors, suggesting that resistance could indeed be blocked in patients with the same drug as in mice.

In this study, tungstate treatment in mouse models of colitis shifted gut microbiota to a more normal state in terms of the balance of bacterial species and also reduced gut inflammation, the researchers report.

In mouse models, oral administration of tungstate, a soluble tungsten salt, in the drinking water selectively prevented the bloom of Enterobacteriaceae in the gut, they said.

With collaborators from India, Japan, and the United States, the inStem lab is exploring «biochemistry, biophysics, humanized mouse models, and single - cell models.»

Adding Cpf1 to its toolbox, CRISPR editing technology can build more diverse mouse models.

Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in mouse models of the disease.

«The next steps are to fully define the role of the interferon response in the development of Down syndrome using mouse models.

So until recently, much of what scientists learned was gleaned by inference or from studying mouse models of the disease.

However, in IBD patients and in mouse models of colitis, Enterobacteriaceae species grow uncontrollably, said Dr. Wenhan Zhu, co-lead author and a postdoctoral researcher in the Winter laboratory.

The current study showed that a deficiency of both SRC - 1 and SRC - 2 inside the fetus» lungs drastically decreased the production of SP - A and PAF, causing a one - to two - day labor delay in mouse models, comparable to a three - to four - week labor delay in women.

One form of pancreatic cancer has a new enemy: a two - drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.

then tested its effectiveness on human pancreatic cells that had been implanted in mouse models.

They found that blocking ANGPTL3 activity with an investigative injectable antibody, known as evinacumab, reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants, and largely reversed signs of atherosclerosis in a mouse models.

We have mouse models for many of these diseases, says Zeng, so we can treat the brains of affected animals with the same dye - and - dice approach.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Geha led an investigation using two separate mouse models of eczema, each recreating a separate pathway leading to allergic skin inflammation.

Working with mouse models of cancer, they demonstrated how treatment with antibiotics on top of chemotherapy may be significantly superior to treatment with chemotherapy alone.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

«Without RORα, allergic inflammation went crazy in both our mouse models.»

So much of what you learn depends on how you ask the questions; we are asking the questions a little differently from the academics who study mouse models.»

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.