No doubt, knowledge of the mouse genome will help scientists design more effective
mouse models for human disease and disorder.
He later combined it with studies on chromatin, tissue specific gene expression and
mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.
Not exact matches
Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a
mouse model of the
disease — potentially laying the groundwork
for a new approach to treating severe cases of
human depression in which drugs are ineffective.
To better understand their findings, the team examined the animal
model for APS1 (i.e.
mice with the same genetic defect as
human patients with the syndrome) and found that male
mice spontaneously developed an inflammatory
disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.
Additionally, work in a
mouse model revealed similar cells, indicating that the progenitors are conserved from
mouse to
human, and therefore, they must be «important cells with promising potential
for cell therapy in treating liver
disease,» explained Dr. Gouon - Evans.
Most animal studies of the
disease are conducted with laboratory
mice that have been genetically engineered and bred to
model ALS, but
for this research, investigators used rats with ALS because they more accurately portray the
disease's variable course in
humans.
«The
mouse models don't recapitulate the
human disease,» said Ravi Basavappa of the National Institutes of Health, which gave Fine one of its 12 Pioneer Awards
for «unusually bold,» high - risk, and potentially high - impact research.
«We think that
for the first time, we have a
mouse model of anorexia that closely resembles the conditions leading up to the
disease in
humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.
Findings from
mouse models suggest that eye examination could be used as a noninvasive screening tool
for human brain
diseases.
But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some of the microbial complexity that makes
mice useful
models for human disease.
Thank you
for airing Joseph Garner's views on the futility of trying to cure
mouse «
models» of
human diseases (29...
«If the
mouse models are indicative of
human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life
for cancer patients.»
However, Dr. Kissler's group discovered that reducing levels of the RGS1 protein did not slow the progression of the
disease in
mouse models, suggesting that it may not offer much potential
for human treatment.
«We hypothesized that this might explain why laboratory
mice, while paramount
for understanding basic biological phenomena, are limited in their predictive utility
for modeling complex
diseases of
humans and other free - living mammals,» said Rosshart.
Investigating
mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse models for biological
for research The congress aims to promote the International
Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
Mouse Phenotyping Consortium (IMPC)
mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse lines, importance of
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal
models for human diseases» and recent developments in
mouse models phenotyping ima
mouse models phenotyping imaging.
Historically, researchers have generated their own lines of knockout
mice to serve as
models for human disease, such as heart
disease or cancer.
Infrafrontier — The
mouse is an important
model organism
for studying
human disease.
Since genetic loss of aP2 in
mouse models and in
humans results in lowered risk of cardiometabolic
disease, the molecule offers an exciting opportunity
for new intervention strategies.
During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required
for implementing a sustainable INFRAFRONTIER Research Infrastructure
for systemic phenotyping, archiving and distribution of
mouse models of
human diseases:
Capacity building to meet the increasing demand of the biomedical research community
for systemic phenotyping, archiving and distribution of
mouse models of
human diseases.
BETHESDA, Md., Wed., Oct. 5, 2005 - The National Institutes of Health (NIH) today announced contracts that will give researchers unprecedented access to two private collections of knockout
mice, providing valuable
models for the study of
human disease and laying the groundwork
for a public, genome - wide library of knockout
mice.
This
mouse model for AIDS dementia mimics several features of the
disease process found in
humans.
For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other syste
For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic
disease models (
for example in mouse) by mapping to human or other syste
for example in
mouse) by mapping to
human or other systems.
It now looks like many of these traits could be controlled by the combination of genes between different strains, thus producing
mice that are better
models for human disease.»
«This is an interesting paper presenting a potentially useful preventative therapy
for Alzheimer's
disease but, while
mouse models are very useful, we have to be very careful about the interpretation of the data in relation to the
human condition.
for example, no HD
mouse model shows signs of «chorea», the dance - like movements that are a common feature of the
human disease.
PHENOMIN's involvement in the IMPC will fulfill a key item of the the National Alliance
for life sciences and health (AVIESAN) strategic plan that consists in applying
mouse genetics to analyze the mechanisms of
disease and to use this knowledge
for advancing fundamental research and
human health (AVIESAN report on the use and needs of
mouse models in the French scientific community, 2010).
Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in
human cells and
mouse models, we hope to identify the critical drivers of this
disease and the basis
for therapeutic responses.
These
mice will be preserved in repositories and made available to the scientific community representing a valuable resource
for basic scientific research as well as generating new
models for human diseases.
The results were obtained from
mice and
human stem cells in cultivated brain tissue, and from a series of rodent
models for human neurodegenerative
diseases and acute brain injuries.
The congress aims to promote the International
Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
Mouse Phenotyping Consortium (IMPC)
mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse lines, importance of
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping ima
mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare
diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal
models for human diseases» and recent developments in
mouse models phenotyping ima
mouse models phenotyping imaging.
Mouse models are useful
for studying Alzheimer's
disease, but they have their limitations when comparing results in
humans.
«Our findings reveal a critical role
for telomere length in a
mouse model of age - dependent
human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This
model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent
disease and also a system to test novel therapeutics
for aortic valve
disease.»
We are developing in vivo
models for the
disease in the
mouse, and in vitro
models starting from
human pluripotent stem cell lines.
Recently,
mouse neural stem cells (NSCs) have been shown capable of reprogramming into a pluripotent state by forced expression of Oct3 / 4 and Klf4; however it has been unknown whether this same strategy could apply to
human NSCs, which would result in more relevant pluripotent stem cells
for modeling human disease.
We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis
for the genetic form of Alzheimer's
disease in
humans, directly interferes with gut function as shown here
for the
disease model mice.
The BAC (Bacterial Artificial Chromosome)
mouse model of Huntington's
disease expresses the full length
human htt transgene and has been well - characterized
for its progressively impaired motor function.
These experiments are innovative because they seek to improve a
mouse model based on current knowledge from
human disease, while also testing novel therapies that could be of benefit
for affected individuals.
Although the
mouse remains the most cost - effective choice
for comprehensive phenotyping, the rat remains a better
model for a number of
human conditions, including cardiovascular
disease, diabetes and behavioral disorders.
This innovative
model allows the researchers to test viable new drugs
for this
disease, and it provides a potential solution to studying other
human disorders of aging in
mice.
His research focuses on understanding the role of genetic variation in contributing to
human health and
disease using
mouse models of
human disease, and more recently exploiting technologies developed
for biomedical research
for application in the field of genetic pest management.
Dr. Sawyer's more recent work in prostate cancer has defined critical signaling pathways
for disease initiation and progression through studies in
mouse models and
human tissues.
These kind of
mice are an extraordinary resource
for modeling human disease;
for instance, research has found that
mice that are genetically mutated to carry the BRCA1 gene (a
human breast cancer gene) behave more similarly to
human cancer patients than those
mice who have had a tumor physically transplanted in.
The
mouse makes an excellent
model for human disease because the organization of their DNA and their gene expression is similar to
humans, with ninety - eight percent of
human genes having a comparable gene in the
mouse.
«Of
mice and men — are
mice relevant
models for human disease?»
«With the idea to develop a
mouse model for the rare
human disease ALD, we reached out to genOway to help us in finding the best approach
for this project.
THE
MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wo
FOR CYSTIC FIBROSIS, as with
models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wo
for many
diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of
human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine
for his wo
for his work.
Using a
mouse model for this
disease, which in
humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the
disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.
More than 200 investigators from more than 100 institutions in 17 countries have come to the MMPC to learn strategies
for studying
mouse models of
human disease.
«With the idea to develop a
mouse model for the rare
human disease ALD, we reached out to genOway to help us in finding...»