Sentences with phrase «mouse models for human diseases»

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

No doubt, knowledge of the mouse genome will help scientists design more effective mouse models for human disease and disorder.

Not exact matches

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved from mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver disease,» explained Dr. Gouon - Evans.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«The mouse models don't recapitulate the human disease,» said Ravi Basavappa of the National Institutes of Health, which gave Fine one of its 12 Pioneer Awards for «unusually bold,» high - risk, and potentially high - impact research.

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

Findings from mouse models suggest that eye examination could be used as a noninvasive screening tool for human brain diseases.

But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some of the microbial complexity that makes mice useful models for human disease.

Thank you for airing Joseph Garner's views on the futility of trying to cure mouse «models» of human diseases (29...

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

However, Dr. Kissler's group discovered that reducing levels of the RGS1 protein did not slow the progression of the disease in mouse models, suggesting that it may not offer much potential for human treatment.

«We hypothesized that this might explain why laboratory mice, while paramount for understanding basic biological phenomena, are limited in their predictive utility for modeling complex diseases of humans and other free - living mammals,» said Rosshart.

Investigating mouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models for biological for research The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Historically, researchers have generated their own lines of knockout mice to serve as models for human disease, such as heart disease or cancer.

Infrafrontier — The mouse is an important model organism for studying human disease.

Since genetic loss of aP2 in mouse models and in humans results in lowered risk of cardiometabolic disease, the molecule offers an exciting opportunity for new intervention strategies.

During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:

Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of mouse models of human diseases.

BETHESDA, Md., Wed., Oct. 5, 2005 - The National Institutes of Health (NIH) today announced contracts that will give researchers unprecedented access to two private collections of knockout mice, providing valuable models for the study of human disease and laying the groundwork for a public, genome - wide library of knockout mice.

This mouse model for AIDS dementia mimics several features of the disease process found in humans.

For example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systeFor example, cross-model comparisons may help to pinpoint key cell types and molecules involved in lineage decisions, reveal evolutionary inventions, and may allow to interpret genetic disease models (for example in mouse) by mapping to human or other systefor example in mouse) by mapping to human or other systems.

It now looks like many of these traits could be controlled by the combination of genes between different strains, thus producing mice that are better models for human disease.»

«This is an interesting paper presenting a potentially useful preventative therapy for Alzheimer's disease but, while mouse models are very useful, we have to be very careful about the interpretation of the data in relation to the human condition.

for example, no HD mouse model shows signs of «chorea», the dance - like movements that are a common feature of the human disease.

PHENOMIN's involvement in the IMPC will fulfill a key item of the the National Alliance for life sciences and health (AVIESAN) strategic plan that consists in applying mouse genetics to analyze the mechanisms of disease and to use this knowledge for advancing fundamental research and human health (AVIESAN report on the use and needs of mouse models in the French scientific community, 2010).

Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.

These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.

The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.

The congress aims to promote the International Mouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imaMouse Phenotyping Consortium (IMPC) mouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse lines, importance of mouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse phenotyping & clinical and drug discovery collaboration, to present progresses performed by IMPC with regards CRISPR editing genome, rare diseases, microbiota and ageing pipeline, as well as illustration of examples of scientific projects about «Animal models for human diseases» and recent developments in mouse models phenotyping imamouse models phenotyping imaging.

Mouse models are useful for studying Alzheimer's disease, but they have their limitations when comparing results in humans.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

We are developing in vivo models for the disease in the mouse, and in vitro models starting from human pluripotent stem cell lines.

Recently, mouse neural stem cells (NSCs) have been shown capable of reprogramming into a pluripotent state by forced expression of Oct3 / 4 and Klf4; however it has been unknown whether this same strategy could apply to human NSCs, which would result in more relevant pluripotent stem cells for modeling human disease.

We therefore suggest that the presence of the mutated transgenes (AβPP and PS1), which are per se the basis for the genetic form of Alzheimer's disease in humans, directly interferes with gut function as shown here for the disease model mice.

The BAC (Bacterial Artificial Chromosome) mouse model of Huntington's disease expresses the full length human htt transgene and has been well - characterized for its progressively impaired motor function.

These experiments are innovative because they seek to improve a mouse model based on current knowledge from human disease, while also testing novel therapies that could be of benefit for affected individuals.

Although the mouse remains the most cost - effective choice for comprehensive phenotyping, the rat remains a better model for a number of human conditions, including cardiovascular disease, diabetes and behavioral disorders.

This innovative model allows the researchers to test viable new drugs for this disease, and it provides a potential solution to studying other human disorders of aging in mice.

His research focuses on understanding the role of genetic variation in contributing to human health and disease using mouse models of human disease, and more recently exploiting technologies developed for biomedical research for application in the field of genetic pest management.

Dr. Sawyer's more recent work in prostate cancer has defined critical signaling pathways for disease initiation and progression through studies in mouse models and human tissues.

These kind of mice are an extraordinary resource for modeling human disease; for instance, research has found that mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those mice who have had a tumor physically transplanted in.

The mouse makes an excellent model for human disease because the organization of their DNA and their gene expression is similar to humans, with ninety - eight percent of human genes having a comparable gene in the mouse.

«Of mice and men — are mice relevant models for human disease?»

«With the idea to develop a mouse model for the rare human disease ALD, we reached out to genOway to help us in finding the best approach for this project.

THE MOUSE MODEL FOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his woFOR CYSTIC FIBROSIS, as with models for many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wofor many diseases, owes its existence to a technique called gene targeting, which was developed in the 1980s by Mario Capecchi, a professor of human genetics and biology at the University of Utah who won the 2007 Nobel Prize in Physiology or Medicine for his wofor his work.

Using a mouse model for this disease, which in humans involves the destruction of white matter in the brain, a research team led by Albee Messing, director of the UW — Madison Waisman Center, found that a protein behind the symptoms of the disease, called GFAP, is broken down more rapidly in the body than researchers previously found in cell culture studies.

More than 200 investigators from more than 100 institutions in 17 countries have come to the MMPC to learn strategies for studying mouse models of human disease.

«With the idea to develop a mouse model for the rare human disease ALD, we reached out to genOway to help us in finding...»