The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least
in mouse models of human disease.
«The generation of detailed phenotypic information for each knockout mouse strain will be a boon to disease researchers who want to determine the function of genes and to
improve mouse models of human disease,» said NIH Director Francis S. Collins, M.D., Ph.D. «I am grateful to all of the people and programs across NIH who are supporting this effort and to our international partners who have joined us in this scientific endeavor.»
It creates customisable and high -
scale mouse models of human disease or displaying an abnormality (KI, KO mouse models) and it provides a complete phenotyping characterisation of the immune system by polychromatic and mass cytometry measuring more than 50 simultaneous quantitative parameters in standardised conditions.
KOMP2 postdoctoral fellows will work collaboratively to screen and characterize an expected 30 % of embryonic lethal mutants from more than 800 mouse strains that JAX is characterizing as part of an international effort to functionally annotate the mouse genome and
generate mouse models of human disease.
During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution
of mouse models of human diseases:
Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of
mouse models of human diseases.
The findings, published recently in Nature, uphold
the mouse model of human disease, but pinpoint important differences in gene expression that will guide future health research.
Technical approaches of
mouse model of human diseases.