Sentences with phrase «mouse models of the disease»

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

So until recently, much of what scientists learned was gleaned by inference or from studying mouse models of the disease.

Recently research published in Cancer Discovery showed that changing the schedules of drug administration can improve outcomes leading to more complete responses in mouse models of the disease.

Blocking this inflammation after radiation therapy brought a significant improvement in survival in a mouse model of the disease.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

He returned to St. Louis and shifted several members of his lab to studying Zika, including developing mouse models of the disease.

But in studies of mouse models of the disease, cyclodextrins, even when administered peripherally, have significantly impacted the neurological damage; it's not known how.

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet - B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

In mouse models of disease, Yale researchers looked at the effects of providing nutrients during infection and found opposing effects depending on whether the infections were bacterial or viral.

Because of these limitations, most pancreatic cancer research relies on genetically engineered mouse models of the disease, which can take up to one year to generate.

An international research team led by biochemists at The University of Texas Health Science Center at Houston (UTHealth) reduced the sickling of red blood cells in a mouse model of the disease.

Creating a useful mouse model of disease can take years.

The discovery was made by developing a mouse model of the disease that enabled researchers to track which of 15 genetic groups — or subclones — of myeloma cells spread beyond their initial site in the animals» hind legs.

Blocking this process with a small - molecule drug prevented the characteristic brain plaques and memory loss in a mouse model of the disease.

By depriving the cancer cells of the amino acid cystine, the researchers were able to trigger a form of cell death called necrosis in mouse models of the disease.

Strong evidence from a mouse model of the disease further confirms these mutations as a cause of aortic disease, and, together, the results point toward possible strategies for managing this inherited form of TAAD.

«CRISPR - based technologies have begun to revolutionize many aspects of cancer research, including building mouse models of the disease with greater speed and greater precision.

The drug has shown positive results in recent studies of mouse models of these diseases.

Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

In mouse models of the disease, tau tangles didn't form after the plaques appeared.

For this study, Jabri and colleagues combined insights and data from celiac disease patients who had been cared for at the University of Chicago's Celiac Disease Center with experiments using a mouse model of the disease developed in her lab.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

In 1998, Greg Cox identified the first mouse model of this disease called nmd2J which is still the only model of SMARD utilized for research.

Social behaviors can be assessed with computer vision in mouse models of disease in a home cage environment T. HANANIA, P. KABITZKE, M. MAZELLA, I. FILIPOV, V. ALEXANDROV, D. BRUNNER... Abstract / Posters

These plaques are extracellular aggregations of a small protein called beta - amyloid that are prominent in diseased patients» brains, as well as in mouse models of the disease.

Jefferson College of Pharmacy researchers are developing a new treatment approach based on nanotechnology that was recently shown to be effective in mouse models of the disease.

My research goal is to improve a mouse model of this disease by introducing pro-inflammatory cues, and to experiment with a method of decreasing inflammation in the eye to test the idea that localized control of inflammation could help protect vision.

Moreno H, Lewandowski N, Bordelon Y, Brickman A, Angulo S, Khan U, Muraskin J, Griffith E, Wasserman P, Menalled L, Vonsattel J.P, Marder K, Small S.ARegional vulnerability in Huntington's disease: fMRI - guided molecular analysis in patients and a mouse model of disease.

Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

MIT's Li - Huei Tsai, Ed Boyden, and their colleagues have shown that stimulating neurons to produce gamma waves at a frequency of 40 Hz reduces the occurrence and severity of several Alzheimer's - associated symptoms in a mouse model of the disease.

Miller is widely recognized for his research on the impact of toxins in Parkinson's disease (PD) and has created a unique mouse model of the disease to develop biomarkers of exposure, risk and early disease.

Most Alzheimer's research and drug development are done in mouse models of the disease.

The concept is based on previous work showing that similar compounds had positive effects on mouse models of the disease.

Insight into the processes to which these genes contribute is exploding as researchers assess the effects of the alterations, and pharmaceutical companies are using the resulting mouse models of disease to develop drugs.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans.

We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.

Guo and his collaborators continue their studies by establishing additional mouse models of leukemia that have been transplanted with patient cells of relapsed and refractory disease.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

The new research investigated the effectiveness of MSC therapy in a mouse model of chronic inflammatory lung disease, which reflects some of the essential features of diseases such as COPD and cystic fibrosis.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.