Sentences with phrase «mouse olfactory»

Furudono, Y.; Cruz, G.; Lowe, G. (2013) Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli.

The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000.

Even less is known about the assembly of the neural net within the mouse olfactory system, which, in the end, enables the individual to distinguish one smell from another with astonishing specificity and to remember such distinctions over time.

These unique 3 - D reconstructions of mouse olfactory cells, which govern the sense of smell, were obtained using X-ray imaging tools at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab).

Searching for an explanation to this alternate pheromone - detection system, neuroscientists Stephen Liberles and Linda Buck of the Fred Hutchinson Cancer Research Center in Seattle scanned the mouse olfactory epithelium for potential pheromone receptors.

A team led by Linda Buck of Harvard Medical School in Boston was able to test this proposition with mouse olfactory nerve cells.

Somehow, the mouse olfactory system had to evolve a way to adjust, to encode incoming sensory information so that it doesn't saturate the firing range of olfactory neurons.»

Experiments by the CSHL team explain how these components of the mouse olfactory bulb estimate the total activity across the bulb.

Published in Neuron, scientists at Cold Spring Harbor Laboratory (CSHL) report their discovery of a neural circuit in the mouse olfactory bulb that explains how our mammalian cousins (and by extension, we) are able to adjust the gain on intense odors.

Two - photon microscopy image of a layer of the mouse olfactory bulb (viewed head - on from the front) containing relay stations call glomeruli — places where bundles of axons and dendrites meet.

Neurons in the mouse olfactory bulb fire in a relatively narrow range, up to a few hundred times per second.

Not exact matches

Very gladly would I learn what face things present to a mouse or a bee; more gladly still would I perceive the olfactory world charged with all the information and emotion it carries for a dog.

The finding is based on the results of experiments that saw the connection between temporary elimination of olfactory, smell system, neurones in the noses of adult mice, and weight loss.

So if you look at whole brains, the bulbs look like these tiny afterthoughts; if you look at a mouse or a rat, the olfactory bulb seems quite big.

Rodriguez's team exposed olfactory mouse neurons in the lab to disease - causing bacteria and the urine of sick mice.

GDF - 11, which regulates the growth of spinal and olfactory (smell) receptors, is produced abundantly in young mice, but production drops off with age.

The researchers scoured the already deciphered mouse genome, looking for genes that might encode additional receptor proteins in its olfactory system, the sensory cells that connect the nose to the brain.

In another study of mice injected with GDF11, postdoc Lida Katsimpardi and others in the lab of Harvard neuroscientist Lee Rubin found that GDF11 also encourages growth of new blood vessels and olfactory neurons in the mouse brain.

In the new study, Datta and his team discovered that necklace neurons in mice do not express GPCRs, unlike all other types of olfactory sensory neurons in mammals.

Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally anosmic — unable to smell.

However, mice lacking Ggamma13 in their olfactory cells required more than 8 minutes to perform the same task.

Paying attention to the fact that each olfactory sensory neuron (OSN) expresses an OR, Shun «ichi Kuroda, Professor and Nobuo Yoshimoto, Specially Appointed Associate Professor at the Department of Biomolecular Science and Reaction, The Institute of Scientific and Industrial Research, Osaka University in cooperation with Masato Suzuki, Chief Researcher, Advanced Research Division, Panasonic Corporation made a system in which OSNs from mice were applied to a microchamber array on a microscope slide and fluorescence was yielded when ORs responded to odorants.

The team was able to view the responses of tens of neurons at a time to signals arriving in the olfactory bulb from the mouse's odor detectors, called olfactory sensory neurons, located in the nose.

The scientists focused on the production of new neurons in adult mice, in particular those neurons that integrate into the olfactory bulb, the brain region responsible for analyzing odors.

Lawrence Katz of the Duke University Medical Center and his colleagues discovered that once signals reach the accessory olfactory bulb they are mapped out into distinct patterns of nerve cell activity that vary according to the traits that enable a mouse to identify desirable mates, such as species and sex.

Now researchers report that by inserting ultra-fine electrodes into the brains of live mice, they have identified which neural cells in the accessory olfactory bulb fire when one mouse checks out another's pheromonal fingerprint.

Normal mice with p16 had fewer neural stem cells in one part of the brain and fewer new neurons in the olfactory bulb, again demonstrating p16's ability to inhibit regeneration.

A cross-section of the olfactory bulb of a mouse is shown here; relatively youthful cells, born during the animal's adulthood, glow green.

Whereas 65 percent of new neurons in wild mice ended up in the olfactory bulb, little more than 9 percent of the mutants» neurons were able to complete the journey.

Mark Albers uses the olfactory system of mice and humans to help understand the early events of neurodegeneration in order to find ways to intervene early in the disease process before symptoms appear and distinguish early pathologic events from changes produced by aging.

Transcriptomic and Proteomic Profiling Revealed High Proportions of Odorant Binding and Antimicrobial Defense Proteins in Olfactory Tissues of the House Mouse — Barbora Kuntová — Frontiers in Genetics

«This is the first study to examine olfactory systems in adult mice with regard to the potential to reverse the behavioral and neuroanatomical effects of emotional learning using extinction,» said Morrison.

These are the questions guiding the work of Florin Albeanu, who is using the olfactory bulb and olfactory cortex of mice as the subject of his current studies.

We found widespread expression of Chd7 in early development of the mouse in organs affected in CHARGE syndrome including eye, olfactory epithelium, inner ear and vascular system.

Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.

Citation: Ibarra - Soria X, Levitin MO, Saraiva LR, Logan DW (2014) The Olfactory Transcriptomes of Mice.

Effects of neonatal treatment with valproic acid on vasopressin immunoreactivity and olfactory behaviour in mice.

In the present study we have reported the transcriptional profile of the two main components of the olfactory system in mice, obtained by RNAseq and expression microarray.

The olfactory (OR) and vomeronasal receptor (VR) repertoires are collectively encoded by 1700 genes and pseudogenes in the mouse genome.

Among the behavioral responses elicited through olfactory signals, many are clearly distinct between adult male and female mice, including sexual conduct [3], [4], [6], aggressive responses to intruders [2], and parental care [16], but the mechanisms that ensure such differentiated responses have not yet been fully elucidated in mammals [17].

The sense of smell in mice involves the detection of odors and pheromones by many hundreds of olfactory and vomeronasal receptors.

We asked whether the increase in neural stem and progenitor cells could produce a subsequent change in olfactory neurogenesis in the Het - O mice.