Sentences with phrase «mouse orthologs»

TCF class is a classification of human transcription factors (TFs) and their mouse orthologs based on the characteristics of their DNA - binding domains.

Whereas 12 of 16 annotations were confirmed by RT - PCR in human tissues, for only seven genes mouse orthologs could be identified and found to be expressed.

All human and mouse orthologs are one to one.

Not exact matches

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Gene expression divergence levels were obtained from [71] and were measured in terms of the number of commonly co-expressed genes between human and mouse one to one orthologs.

Although CRISPR is incredibly useful for generating mutations by NHEJ and generating small mutations with HDR, when it comes to larger scale genome editing, such as replacement of a mouse gene with its human ortholog (greater than 5 kb), it remains to be seen whether CRISPR is as robust as conventional gene targeting.

Bottom 10 % CCGs are the genes with the least amount of co-expressed orthologs shared between human and mouse, these genes are likely to have divergent expression patterns between both species.

BioGPS presents data in an ortholog - centric format, which allows users to display mouse plugins next to human ones.

We integrate functional genomic datasets with up - to - date gene and genome annotations, Gene Ontology and pathway annotations, gene orthologs, gene interactions, and a comprehensive set of miRNA - target predictions for human, mouse, zebrafish, and nematode.