Sentences with phrase «mouse ovarian cells»

Not exact matches

Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells» resistance to paclitaxel.

Shih, Wang and their colleagues tested fostamatinib's power to reduce tumor size in mice implanted with human ovarian cancer cells that were resistant to paclitaxel.

The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found ovarian cancer cells to be highly sensitive to these drugs in several different mouse cancer models — even among cells resistant to standard chemotherapy.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

They systematically deleted genes for secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

But the discovery of vast numbers of immature eggs dying in the ovaries of mice led Tilly's team to find what they claim are hidden ovarian stem cells that can sprout new eggs to replace

After receiving a transplant of ovarian cancer cells, mice were restrained to cause stress.

While previous research had shown some effectiveness of this molecule in a mouse model of ovarian cancer, that benefit was limited by the immunosuppressive environment within tumors, particularly the presence of regulatory T cells (Tregs).

They then tested the circuit in mice implanted with ovarian cancer cells, and demonstrated that it could trigger T cells to seek out and kill the cancer cells without harming other cells around them.

In another set of experiments, the team implanted human ovarian carcinoma cells into mice.

Recent studies have demonstrated that mouse ES cells can differentiate into female and male germ cells in vitro, thus producing ovarian follicle - like structures [1], [4] and testicular germ cells 2, 3.

To prepare ovarian cells, ovarian tissues were isolated from 1 - day - old F2 female mice produced by interbreeding C57BL6 × CBA F1 mice.

In the case of EB formation using mouse testicular or ovarian cell - conditioned medium (see below), the EBs were cultured in ES medium for 24 hr, and then in a conditioned medium.

The research team confirmed those results by testing the four compounds at a low dose in mice injected with ovarian cancer cells.

Pregnant mice ate the high - fat diet starting at gestation day 10, the time when a daughter's ovarian eggs (and germ cells) begin to develop.