Sentences with phrase «mouse ovaries»

We thus confirmed that the predominant expression of Boule during reproductive development is in the adult testis, including a testis - specific isoform, and also identified previously unreported low levels of Boule RNA in mouse ovaries.

During the last decade, some researchers have claimed that primordial follicles in adult mouse ovaries turn over and that females use adult germ - line stem cells to constantly resupply the follicle pool and sustain ovulation.

In experiments with mouse ovaries inhibiting the identified enzymes saved the oocytes from cell death despite treatment with chemotherapeutics.

Dormant eggs in mouse ovaries have been awoken and used to create healthy pups.

Not exact matches

Researchers have injected mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors, and their new drug has killed the tumors every time.

Researchers implanted 3 - D - printed ovaries into sterile female mice that later gave birth.

Next, they implanted two ovaries each in seven sterile mice, and mated them with male mice.

When the researchers paired female mice treated with the gene therapy with males, the females were still able to become pregnant — and have healthy babies — within the first six weeks, because of those follicles that had already started growing in the ovaries.

The ovaries were then transplanted back into the mice, and they received a hormone to stimulate egg development.

In the ovary of a mouse treated with Müllerian - inhibiting substance, follicle development ceased and only primordial follicles were found (arrows, right).

Twenty healthy mouse pups were born after fertilised eggs from the treated ovaries were implanted into surrogate mothers (Proceedings of the National Academy of Sciences, DOI: 10.1073 / pnas.1001198107).

In the ovary of a normal mouse (left), a large follicle is shown at a late stage of development (a light pink oocyte surrounded by follicular cells, inset).

Researchers also found a type of immune cell (multinucleated macrophage giant cells) in the ovaries of reproductively «old» mice only.

They also found ovaries from mice of advanced reproductive age expressed genes and produced proteins that are highly inflammatory.

Then the team sought to bring estrogen into the picture, turning to mice whose ovaries had been removed and who were given supplemental estrogen.

EGG - CITING DEVELOPMENT Germline stem cells (orange circles, left) implanted into a mouse's ovary move to the edge of the ovary (middle) and begin developing into eggs.

To create cloned mice, the team inserted nuclei from so - called cumulus cells, which surround the ovary, into egg cells, or oocytes, without nuclei.

When the researchers looked for prostaglandins in COX - deficient mice models from Vanderbilt using mass spectroscopy tests, the signaling molecules were there — and not just in the ovaries.

They expected eggs to be more complex, but last year, Hayashi made PGCs in vitro with cells from a mouse with normal coloring and then transferred them into the ovaries of an albino mouse.

Patricia Hunt (then working at Case Western Reserve University) was studying the endocrine environment of the aging ovary in mice.

When a drug blocking the gene was given to adult female mice, their ovaries started producing more eggs.

Before birth, mouse and human ovaries contain an abundant supply of germ cells, some of which will develop into the eggs that will ultimately be released from follicles during ovulation.

He was conducting laboratory experiments aimed at finding ways to lessen the effects of cancer therapy on ovaries when he noticed that healthy female mice seemed to be losing eggs at unsustainable rates.

But the discovery of vast numbers of immature eggs dying in the ovaries of mice led Tilly's team to find what they claim are hidden ovarian stem cells that can sprout new eggs to replace

This is because older mice lose the capacity to excrete adequate levels of two hormones: one that stimulates egg follicles to grow and mature and another that causes the ripened egg to be released from the ovary into the reproductive tract.

They then surgically removed the ovaries from seven mice and sutured the prosthetic ovaries in their place.

Now, prosthetic ovaries made of gelatin have allowed mice to conceive and give birth to healthy offspring.

When Tilly and his researchers studied mice that lacked the bax gene, they found that 24 - month - old females — the equivalent of 80 - to 100 - year - old humans — still have functioning, estrogen - producing ovaries.

The bioprosthetic ovaries are constructed of 3 - D printed scaffolds that house immature eggs, and have been successful in boosting hormone production and restoring fertility in mice, which was the ultimate goal of the research.

By removing a female mouse's ovary and replacing it with a bioprosthetic ovary, the mouse was able to not only ovulate but also give birth to healthy pups.

To find out whether sex hormones affect the number of neurons devoted to detecting female pheromones, the researchers removed the testes from male mice and the ovaries from females.

Working with mice, Lei and Spradling set out to test their belief that certain undifferentiated germ cells learn to develop into eggs very early during their production in the ovary, when germ cells are found in small clusters of interconnected sister cells, all daughters of the same parent cell.

Although the mice without Bax started out with the same number of oocytes as normal mice, their ovaries harbored about three times as many oocyte - containing follicles shortly after puberty.

Scientists have created a strain of mice with ovaries that essentially remain young until the animals die.

Human egg cells behaved the same way; when human ovary tissue was grafted into mice injected with PAH, the eggs died, the team reports in Nature Genetics online this month.

Tilly and his team examined the ovaries of old mice in which the Bax gene had been «knocked out» in early embryos before they developed.

To test whether sex hormones could account for these differences, the researchers removed the ovaries from female mice and the testes from male mice.

To determine whether treatment with Osteolectin could reverse bone loss after the onset of osteoporosis, the CRI research team used mice that had their ovaries removed to model the type of osteoporosis that develops in postmenopausal women.

Caption: This image shows mouse fetal ovary whose eggs (colored green) were protected from dying by AZT.

At the workshop an extraordinary group of experts in the cryopreservation field brainstormed and discussed in depth the latest technological advances in cryopreservation, including sperm and embryo cryopreservation, updated in vitro fertilization (IVF) methods and related techniques as ovary cryopreservation, laser - assisted and piezo - driven intracytoplasmic sperm injection (ICSI), transportation of frozen material and other technical and logistic challenges relevant to the operation of current mouse embryo / sperm archives.

The Consiglio Nazionale delle Ricerche, European Mouse Mutant Archive (EMMA) Core Structure, Monterotondo Campus and The Jackson Laboratory offer a comprehensive workshop on cryopreservation of mouse embryos, sperm and ovaMouse Mutant Archive (EMMA) Core Structure, Monterotondo Campus and The Jackson Laboratory offer a comprehensive workshop on cryopreservation of mouse embryos, sperm and ovamouse embryos, sperm and ovaries.

Surgical and nonsurgical mouse embryo transfer techniques will be demonstrated, as well as mouse microinsemination (intracytoplasmic sperm injection) and ovary transplantation.

Results showed the first two groups didn't develop PCOS, unlike the mice in the control group, whereas the test subjects with ovary ARs still contracted the disease, albeit at a lower rate than the normal mice.

Immunohistochemical analysis with ab127055 showing Dazl and Boll protein expression during mouse fetal ovary development.

To better understand where in the body these hormones act, researchers administered high doses of androgens to four different groups of mice: a cohort genetically altered to have no ARs, another group that possessed no ARs in the brain, a third one with ARs only in the ovaries, and a control group.

Furthermore, the requirement of mouse Boule for male reproduction and its dispensability for female fertility suggests that low level expression of Boule in embryonic germ cells and adult ovaries is not essential for either the development of germ cells or the production of female gametes.

Although mammalian Boule is highly expressed in the adult mouse testis but not ovary, it is not known if Boule is expressed in the ovary during development [35].

These plans may sound like far fetched science fiction, but two recent relevant breakthroughs in advanced reproductive technologies were announced: 1) the birth of mouse pups from 3D printed ovaries, and 2) the growth of fetal lambs transferred to an artificial uterus part way through pregnancy.

The presence of Stem Cells in the ovaries and their transformation into mature oocytes (egg cells) has been demonstrated in mice by Harvard researchers.

In the study, researchers removed the ovaries of female mice to mimic the effects of post-menopausal women before implanting estrogen - receptor positive cancer tumors into the test subjects.