Sentences with phrase «mouse progenitor cells»

The researchers used mouse progenitor cells lacking PU.1 to explore this mystery.

Encouragingly, the team reports in the same paper that mouse progenitor cells were capable of regenerating entire hair follicles.

«By identifying the signals that instruct mouse progenitor cells to become cells that make tubes and later insulin - producing beta cells, we can transfer this knowledge to human stem cells to more robustly make beta cells, says Professor and Head of Department Henrik Semb from the Novo Nordisk Foundation Center for Stem Cell Biology at the Faculty of Health and Medical Sciences.

Not exact matches

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

But it was another three decades before Klassen — who has used retinal progenitor cells to restore vision in mice, cats, dogs and pigs — could conduct human trials involving retinitis pigmentosa.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

The same observations were made in organoids (artificially grown masses of cells that resemble an organ) created from unique basal progenitor cells that were isolated from the gastroesophageal junction in mice and humans.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

BYE BYE BUDS Mice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (leMice that became obese on a high - fat diet (right) lost a quarter of their taste buds (stained red) and also had fewer progenitor cells (stained green)-- which give rise to new taste buds — than mice of a healthy weight on a regular diet (lemice of a healthy weight on a regular diet (left).

Strikingly, sustaining Pax6 expression in mouse basal progenitors increased their capacity to undergo multiple rounds of cell division, as typically observed in primates.

The LPA receptor is expressed in the brain of human fetuses, just as in mice, and in the same types of neural progenitor cells.

Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved from mouse to human, and therefore, they must be «important cells with promising potential for cell therapy in treating liver disease,» explained Dr. Gouon - Evans.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells.

The mice benefited from human stem cells called glial progenitors, immature cells poised to become astrocytes and other glia cells, the supposed support cells of the brain.

The enhanced mice masterfully memorized new objects, swiftly learned to link certain sounds or situations to an unpleasant foot shock, and displayed un-usually savvy maze navigation — signs of mental acuity that surpassed skills exhibited by either typical mice or mice transplanted with glial progenitor cells from their own species.

To demonstrate the capabilities of SpDamID in the current study, the authors analyzed Notch - mediated transcriptional activation in mouse kidney progenitor cells (mK4 cells).

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

The Duke team had previously established that Type 2 cells produce surfactant and function as progenitors in adult mice, demonstrating differentiation into gas - exchanging Type 1 cells.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Scientists in Germany last year reported that they could transform adult mouse spermatogonial progenitors into cells genetically resembling ESCs by using a different growth medium for just a few weeks.

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

When they deleted the SCF gene in the hair progenitor cells in mouse models, the animal's hair turned white.

Brain neurons are generated from stem cells called basal progenitors that are able to proliferate in humans, but not in mice.

In male mice, however, diet - induced obesity made more active inflammatory white blood cells and enhanced their progenitors.

The scientists therefore conducted tests to see whether in mice, basal progenitors start to proliferate if a comparable cell environment is simulated.

Institute director Catherine Verfaille and her team pulled multipotent adult progenitor cells, referred to as MAPCs (and pronounced map - seas), from the bone marrow of mice and rats.

Using mice deficient in Del - 1, they found that the protein promotes proliferation and differentiation of hematopoetic stem cells, sending more of these progenitor cells down a path toward becoming myeloid cells, such as macrophages and neutrophils, rather than lymphocytes, such as T cells and B cells.

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

«We isolated kidney progenitor cells from mice and searched for the most favorable culture conditions,» said Assistant Professor Shunsuke Tanigawa of Kumamoto University.

To test this, the team took mouse hematopoetic progenitor cells — cells that give rise to white blood cells — and modified them to overexpress a protein called Id3.

They then transplanted progenitors of the inner ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes.

But he adds that the study does not show that human astrocytes are genetically normal when engrafted into the mouse brain, and it does not rule out the idea that the improved learning and memory «could be due to the persisting progenitor cells.»

The team set up a microscope and video camera over several culture dishes, each containing a single neural progenitor cell taken from a mouse embryo 10 days after fertilization.

Now, in a study published in Nature, researchers led by Professor Cédric Blanpain at the Université Libre de Bruxelles, Belgium, and Professor Ben Simons at the University of Cambridge, have demonstrated in mice how skin stem and progenitor cells respond to the activation of an oncogene.

HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone.

Importantly, 25 of the 115 transcripts, shared by EFTF - expressing pluripotent cells and the EF, encode for 15 genes that are both expressed in retinal stem / progenitor cells and required for normal eye formation in frogs, fish, mice, or humans (Figure 1C; Table S1).

Wnt / β - catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse ES cells.

Maturation of human embryonic stem cell - derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.

The authors also show that mice with tumors show an increase in the number of this type of circulating progenitor cells.

Initial reprogramming efforts used adult mouse limbal progenitors (epithelial cells which express Sox2, Klf4, and Myc) which the group reprogrammed to iPSCs using embryonic stem cell CM (ESCM) supplemented with MAPK and GSK3 inhibitors as previously described [4, 5].

In addition, when these inhibitory progenitor cells were transplanted into apoE4 mice with an accumulation of amyloid beta, prior deficits were alleviated.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

The researchers found that a specific stem / progenitor cell population was inhibited following radiation in mice missing Nrf2, and that alveolar type 2 cells in these mice were more likely to change into myofibroblasts — a cell type implicated in fibrosis.

In Neu1 - deficient mice the excessive lysosomal exocytosis results in cleavage of VCAM - 1, loss of bone marrow progenitor cells from the bone niche and the onset of spleenic hematopoiesis.

The team used genetically engineered mice to study the effects of different human apoE variants on the maturation of neural stem cells or progenitor cells, from which new neurons develop in the adult brain.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

Functional rescue of dopaminergic neuron loss in Parkinson's disease mice after transplantation of hematopoietic stem and progenitor cells, EBioMedicine, in press.

In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.