Sentences with phrase «mouse strains with»

Our primary experimental approach involves creation of engineered mouse strains with informative genetic mutations, characterizing these mice and their cells to elucidate molecular mechanisms underlying cancer phenotypes, and verifying these mechanisms in human cancer patient specimens.

We are currently focusing our efforts on an exceptional resource of laboratory mouse strains with proven Mendelian disorders with unknown genetic etiology, strains stewarded by the Mouse Mutant Resource at The Jackson Laboratory for over 50 years.

To overcome this obstacle, mouse strains with Cre recombinase - dependent Cas9 expression have been generated.

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

From this screen, they recovered eight different mouse strains with structural and functional heart defects indicative of HLHS.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

Melvin Bosma discovers a mouse strain with severe combined immune deficiency (SCID).

What's more, transferring the microbiota from one inbred mouse strain with distinct behavior into another inbred (germ - free) strain is sufficient to transfer the host strain's behavior to the recipient7.

Not exact matches

By tinkering with the position of the $ 219 keyboard, and accompanying devices like a joystick or mouse, users will strain their hands and wrists less.

Mice slathered with one strain of Staphylococcus epidermidis that makes the compound developed fewer...

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

In a series of experiments, the researchers found that 95 % of mice vaccinated with the investigational cocktail were protected against a lethal challenge with eight different influenza strains expressing seven different influenza A subtypes, compared to only 5 % of mice who received mock vaccinations.

Although the mouse gut microbiome presents a number of similarities with the human microbiome, the work showed that around 20 percent of the strains in the collection prefer colonizing the intestines of mice.

Mice treated with a strain of S. epidermidis that does not make the compound 6 - HAP and then exposed to ultraviolet rays developed UV - induced tumors (left).

Alf Hamann, from Deutsches Rheuma - Forschungszentrum and Charité Universitätsmedizin Berlin, Germany, and colleagues, did a comprehensive analysis of IL - 27 function in mice infected with a highly pathogenic influenza strain.

Brueckner's group looked for gene defects in two strains of mice with situs inversus, a mutation in which the heart, lungs, and other organs are inverted, like a mirror image.

In their next experiment, Arriaga placed a male strain of mouse that had what's considered a «tenor» voice inside a soundproof cage with a «baritone» so the two mice could only hear each other.

Barbara Rehermann and Stephan Rosshart first collected 800 wild house mice (Mus musculus domesticus) in the Washington, D.C., metro area, and compared their DNA and gut bacteria both with a lab mouse strain and with wild mice from all over the world.

No decreases in dendritic spines were seen in mice that didn't receive flu virus and mice infected with the H1N1 strain.

In mice, message - receiving dendritic spines (bumps in lower panels) were sparse after infections with flu strains H3N2 and H7N7.

Then the researchers looked at the way those strains behaved in mice, ferrets and monkeys compared with two other types of H7N9: a less infectious version that first emerged in 2013 and the one isolated from the patient in 2016.

A new strain of mice with weak bones and stunted growth may become an important tool for researchers to study how bones gradually disintegrate in people who suffer from osteoporosis.

Research with mice also suggested that genetic differences may cause one strain of mouse to gain weight on a diet that helps another strain slim down (SN: 8/20/16, p. 13).

The drug also eased respiratory symptoms and significantly improved survival of mice infected with a pandemic flu strain.

Medawar did not immediately appreciate the link to Owen's work, but when he saw the connection, he decided to inject fetal mice in utero with tissue from mice of a different strain.

The researchers then introduced the two strains into mice transplanted with a human immune system and watched in real time as HIV spread from one CD4 + helper T cell to another.

Bautista, Brem, and collaborators sought out genes whose expression was correlated with itch behavior across genetically distinct mouse strains.

Now, a strain of mice with major balance problems has provided scientists with new clues about the genesis of otoconia.

When a strain of mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected from the development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and autoantibodies than did mice expressing TREML4.

Charged with finding a new remedy for malaria, scientists working for Mao Tse - tung and Chou En - lai decided to test Ge Hang's ancient wormwood recipe in mice infected with a malarial strain that is lethal in rodents.

Mice vaccinated with the newly designed influenza virus, called hyper - interferon - sensitive (HIS) virus, survived exposure to lethal doses of several different influenza A strains.

To prove that the UL6 protein sequence does in fact trigger the autoimmune attack of HSK, Cantor and his team have now infected mice with either normal HSV - 1 or a strain that they had genetically altered to lack the UL6 protein.

The researchers started with a strain of mice that lacked the gene to produce ItpkB.

For now, these are all hypotheticals, given that memory engineering at the cellular level is currently only possible in highly engineered strains of mice who are tricked out with molecular beacons and switches, and whose memories are established in highly stylized ways.

The researchers also tested the pathogenicity of the virus by using it to infect mice, which succumbed more quickly than mice infected with other H5N1 strains.

To see if new mutations helped resistant strains grow stronger, Andersson and his colleagues infected mice with Salmonella typhimurium, which causes food poisoning.

But injecting germ - free mice with IGF - 1 brought their growth on par with the other mice, as did giving them one particular strain of lactobacillus.

Using a specialized gene manipulation technique called chromosome engineering, researchers developed genetically engineered mouse strains in three separate iterations: MYC only, the rest of the region containing PVT1 but without MYC and the pairing of MYC with the regional genes.

By comparing the genome of mice with the HLHS heart defects to the genome of normal mice, Lo and her team identified several hundred mutations in the HLHS mutant strains.

Experiments with two strains of mice, both genetically prone to obesity and diabetes, determined what drove the mice to overeat.

Kempermann and collaborators raised mice of the same strain in the same environment, one full of interesting places to explore and objects to play with.

Enter a mutant mouse strain that is afflicted at a young age with many of the diseases common to older humans.

To test their idea, they did experiments with highly inbred strains mice.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

The team infected mice with the 1918 virus, a modern human flu strain, and hybrids of the two in which either two or five of influenza's eight genes came from the 1918 virus.

Virgin first infected mice with the rodent equivalent of these two herpes strains and then exposed them to two types of bacteria: Listeria monocytogenes, a common cause of food poisoning, and Yersinia pestis, which causes bubonic plague.

Although Jackson Lab probably stocks some 200 strains of mice with disordered personalities, the world still does not have enough — or good enough — crazy mice.

When the researchers vaccinated mice with the Dutch vaccine, the animals were more vulnerable to strains that had the mutations than to ones that didn't.

Prusiner, together with Fred Cohen and his colleagues, also at UCSF, and Ruth Gabizon at Hadassah University Hospital in Israel, used human prions to infect a special strain of laboratory mice.

Researchers engineered seven versions of the Cambodian virus, each with one of the epidemic strains» mutations, and injected the viruses into fetal mouse brains.