Sentences with phrase «mouse studies conducted»

Based on mouse studies conducted both at UW and elsewhere, they anticipate the drug «could increase healthy lifespan of middle - aged dogs by 2 - 5 years or more.»

For example, results of a mouse study conducted by the National Institutes of Health (NIH) in collaboration with ChromaDex published in November 2014 indicated that NR was effective at restoring NAD + levels in mitochondria and rescuing phenotypes associated with a devastating accelerated aging disease known as Cockayne Syndrome (CS).

Not exact matches

They've conducted studies in mice, which showed that the device was able to improve the results of the drug by twelve times.

One 2013 study, conducted in mice, was designed specifically to examine the long - term effects of Ace - K and took place over a 40 - week period.

Because companies have resources — reagents, proprietary mouse models, the ability to conduct toxicology studies, and so on — that even major research universities may lack, Giger says.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Despite the fact that this particular study was conducted on mice, it is clear that maintaining a healthy gut microbiota is key to a healthy lifestyle.

Wyss - Coray, whose group did most of the mouse studies that inspired the clinical trial, now plans to conduct a second, larger trial using plasma from which many proteins and other molecules have been removed.

Although the study was conducted in a mouse model, the outcomes may be applicable to humans,» explains Dr. Jiang.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

To account for this, the researchers conducted their study in several distinct strains of genetically bred mice.

The researchers conducted their studies in mice because patients with mutations in the STIM1 gene and that of the channel it activates, ORAI1, are extremely rare and often too sick to study due to chronic infections and lymphoproliferative disease.

The study, which Shay conducted with colleagues at the University of Florida and University of Nebraska, complements work with mice he leads at his OSU laboratory.

The study, conducted in mice and including analyses of human cancers, found very high levels of two proteins — dectin - 1 and galectin - 9 — in pancreatic tumors.

Roughly 250 published studies about diabetes were conducted using these tainted mice, continues Professor Creemers: «In many of them, researchers were looking to see if a given gene played a role in insulin production.

Using their previously established sporadic PD mouse model, the researchers conducted both prevention and intervention preclinical studies.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

The study, conducted in mice, found that exposure to air pollution during the equivalent of the first or second trimester in humans was linked to more negative birth outcomes than exposure later in pregnancy.

«However, because our study was conducted in mice, this idea needs to be rigorously tested in humans to see if the results would be applicable to people.»

The study was conducted on mice, and the results will be published in the February issue of Journal of Nutritional Biochemistry.

The study was conducted in mice, and many findings from mouse studies do not hold up in people.

After conducting studies in both humans and mice, the researchers said this new schizophrenia risk gene, called C4, appears to be involved in eliminating the connections between neurons — a process called «synaptic pruning,» which, in humans, happens naturally in the teen years.

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

A new study in mice, conducted by researchers at Sweden's Karolinska Institutet together with colleagues in Singapore and the United States, shows that our natural gut - residing microbes can influence the integrity of the blood - brain barrier, which protects the brain from harmful substances in the blood.

The study was conducted on female mice, half of them with cancer and the other half without.

Through studies conducted in mice, Oliver M. Steinmetz, MD (University Hospital Hamburg Eppendorf, in Germany) and his colleagues have shown that the messenger protein IL - 6, which is rapidly produced at high levels during an acute inflammatory form of kidney disease, potently dampens activation of tissue - destructive immune cells called macrophages.

Golombek plans to conduct additional studies to determine sildenafil's effects on female hamsters (the current study only involved males), as well as in mice, a model in which much more is known about circadian clock function.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

Kravitz has a background in studying Parkinson's disease, and when he began conducting obesity research a few years ago, he was struck by similarities in behavior between obese mice and Parkinsonian mice.

The researchers stress that, because the study was conducted with mice, additional research is required before it can confirmed whether the data will apply directly to human health.

Frustrated by the lack of a good study model, Krasnow and his colleagues turned to the mouse lemur and began conducting detailed physiologic and genetic studies on hundreds of these petite, docile creatures in the rainforests of Madagascar.

The MD Anderson team conducted four different studies in which mice were randomized to different diet groups and fed one of four diets.

The study, conducted in mice and in laboratory samples, is published February 10 in Cell Host & Microbe.

They believe this mouse model can be promptly implemented to find genetic markers, conduct meticulous studies on how symptoms originate and take hold, and evaluate drugs and that have broad spectrum anti-viral activities against all Zaire ebolaviruses, including the one responsible for the current West African epidemic.

«Our current studies were conducted in mice, but we hope that one day we will be able to take advantage of the body's natural response to low blood oxygen levels with drugs that mimics low oxygen conditions.

The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age - related memory loss and Alzheimer's disease are distinct conditions.

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

To conduct their study, IU researchers divided adolescent or adult male mice into five groups.

The researchers currently are conducting follow - up studies to determine if the changes caused by exposure to BPA and EE predispose mice to obesity and other metabolic disorders.

To evaluate the safety, an implantation study was conducted in a subcutaneous mouse model.

Increased expression of a gene linked to autism spectrum disorders (ASDs) leads to a remodeling of dendrites during brain development, according to a new study conducted in cultured neurons and an ASD mouse model published in JNeurosci.

We also conduct electrophysiological, biochemical, imaging, antd behavioral studies with various knockout and transgenic mice to determine how precise genetic manipulations that either activate or abolish specific translational control mechanisms alter synaptic function and behavior.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

Studies of stable cell maintenance are being conducted in leukemia stem cells, hematopoietic stem cells, and mouse embryonic stem cells.

These mouse models will help the interpretation of multi-parameter human studies which, in part, need to be conducted with mixed samples.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

They conducted a study in mice and found that the stem cell that produces all the different cells of the skin actually lives in hair follicles.

They conducted a very well designed study that included a large number of mice treated with CTEP in two different ways - for a very short time (1 week), or a prolonged window of 3 months.

«This mouse strain is great model for this research because they are otherwise healthy and normal, including in their vision, so it allows us to conduct studies focused on cell integration,» said the publication's lead author, Jie Zhu, PhD, a postdoctoral researcher who started in Lamba's lab three years ago.