Sentences with phrase «mouse studies reported»

Yet a mouse study reported in May by Mark Kay's lab at the Stanford University School of Medicine delivered some sobering news about RNAi.

Not exact matches

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrated.

In a University of California, San Diego School of Medicine study published July 13 in the online journal Nature Neuroscience, a research team led by Takaki Komiyama, PhD, assistant professor of neurosciences and neurobiology, reports that in mouse models, the brain significantly changed its visual cortex operation modes by implementing top - down processes during learning.

«The newborn mice inherited a very altered, skewed population of microbes,» said Eugene B. Chang, MD, Martin Boyer Professor of Medicine at the University of Chicago, Director of the Microbiome Medicine Program of the Microbiome Center, and senior author of the study, published this week in the journal Cell Reports.

For decades, wildlife documentaries have promoted the idea that Komodo dragons owe their success as predators to toxic bacteria in their saliva — a claim bolstered by a 2002 study reporting deaths among lab mice injected with their saliva.

Published in the journal Scientific Reports, the study investigated how a single bout of intense exercise could reduce olanzapine - induced hyperglycemia in male mice.

The study found that a mother mouse can pass along to her offspring a susceptibility to intestinal disorders, such as inflammatory bowel disease, by way of a gut - residing bacterium called Sutterella, the researchers reported in the journal Nature on Feb. 16.

In a study published in Nature Communications, the investigators report that hyperglycemic mice (or mice with type 2 diabetes) have a 24-fold higher accumulation of succinate, an intermediate metabolite, in the metabolic pathways of their bone marrow stromal cells.

Cells engineered to produce insulin under the command of a smartphone helped keep blood sugar levels within normal limits in diabetic mice, a new study reports.

In a report on the study, published Feb. 5 in Nature Neuroscience, researchers say the biochemical receptor, known as a G protein - coupled receptor, was present on nerve cells in the lower respiratory tracts of lab mice.

In this study, Cherqui's team transplanted wildtype HSPCs into an FA mouse model, reporting that the HSPCs engrafted and soon differentiated into macrophages in key regions of the mice's brain and spinal cord where they appeared to transfer wildtype FXN into deficient neurons and muscle cells.

But a study of mice shows that breast cancer cells decamp in groups, and the clumps of cells have a better chance of establishing a colony than loners do, Kevin Cheung of Johns Hopkins University reported December 7 at the annual meeting of the American Society for Cell Biology.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

As reported in a paper published online in the New England Journal of Medicine, researchers from Penn Medicine, Regeneron Pharmaceuticals, and a group of international collaborators studied ANGPTL3 in both humans and mice.

In a study in Nature Medicine, the team reported that vaccinated mice and ferrets appeared to be protected from dying of the H5N1 bird flu after receiving the vaccine, even when they developed symptoms.

In this study, tungstate treatment in mouse models of colitis shifted gut microbiota to a more normal state in terms of the balance of bacterial species and also reduced gut inflammation, the researchers report.

A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice.

But a new study reports that these tiny flecks of carbon can shrink tumors in mice by delivering chemotherapy drugs to cancer cells.

Reporting their study data Sept. 22 in the journal Immunity, scientists at Cincinnati Children's Hospital Medical Center say their findings in mice should also provide insights into new therapeutic strategies and diagnostics for food allergies and anaphylactic shock triggered by the immune antibody IgE (immunoglobulin E).

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

«This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition,» says Eloise Hudry, PhD, of MGH - MIND, lead author of the Science Translational Medicine report.

A study reported in the Gut journal has shown that in mice, bacterial imbalance in the gut can lead to an inflammation similar to Crohn's disease, and this can be transmitted to other animals.

In a report about their study published online Oct. 17 in Clinical Cancer Research, the researchers described minimal or zero tumor progression in mice treated with the microencapsulated 3BrPA.

In a study published in the journal Cell Reports, Drs. Per Nilsson, Takaomi Saido and their team show for the first time using transgenic mice that a lack of autophagy in neurons prevents the secretion of amyloid beta and the formation of amyloid beta plaques in the brain.

Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.

In a new study, National Institutes of Health (NIH) scientists report they can detect infectious prion protein in mouse brains within a week of inoculation.

After Mikovits and her research team's Science study appeared in October 2009, many other groups around the world reported that they could not find the mouse retrovirus, dubbed XMRV, in people who had CFS.

«Unlike previously reported short - term studies, this is the first time the effects of long and thin carbon nanotubes, leading to mesothelioma, have been monitored in mice over many months,» says senior author Marion MacFarlane, a Professor at the Medical Research Council (MRC) Toxicology Unit in Leicester, UK.

Two new studies, on pain receptors and a mouse model for congenital blindness, now report significant advances toward the realization of this goal.

Thomas L. Kash, PhD, associate professor of pharmacology and the lead author of the study published in the journal Cell Reports, used mice to show the effects of KORs on behavior.

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males.

In a study published June 27 in Cell Reports, a team led by Thomas Rando, MD, PhD, professor of neurology and neurological sciences and chief of the Veterans Affairs Palo Alto Health Care System's neurology service, has identified characteristic differences in «histone signatures» between stem cells from the muscles of young mice and old mice.

In a study reported late last year in the British Journal of Pharmacology, AM6545 enabled mice and rats to lose weight without inducing signs of depression or nausea.

In the second study, reported online today in Nature, researchers were also able to reactivate an old memory in mice.

In the treated mice, the treatment strongly reduced the tumor growth with no toxicity to the mice, reports the study in Oncotarget.

In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.

While the research reported in this paper manipulated pluripotent mouse cells, the researchers have moved ahead in performing similar studies with human stem cells and achieved comparable types of results with the microparticle delivery approaches.

In a report on the mouse studies, published online Sept. 11 in PNAS (Proceedings of the National Academy of Sciences of the United States of America), the investigators say the genetic alteration appears to release the biochemical «brakes» on brain cells involved in body movement, reasoning and perception of the world, triggering over-excited activity and reactions.

In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal model.

In a study appearing in Science Translational Medicine, the researchers report they have effectively and safely employed this stem cell - targeting system in mice to treat metastatic breast cancer that had spread to the lung.

The FDA - approved drug fluoxetine, also known by the brand name Prozac, restored levels of a key neurotransmitter and improved behavior in mice with an autism - like disorder, a new study in the June 21 issue of Science Advances reports.

A new study from the University of Illinois reports long - lasting cognitive impairments in mice when they are administered a chemotherapy regimen used to treat breast cancer in humans.

The study, published in Cell Reports, involved giving cancer drugs to mice and inducing uveitis, an incurable autoimmune eye condition responsible for 1 in every 10 cases of visual impairment in the UK.

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

In a study reported in Nature Neuroscience, they succeeded in shutting down a neuronal mechanism by which memories of fear are formed in the mouse brain.

The reductions in hepatic lipid content and steatosis observed following WBV in male db / db mice in the current study are also consistent with a recent report in female db / db mice (45).

The lower value for the twitch / tetanus ratio observed in this study is consistent with a previous report noting lower twitch / tetanus ratio values in muscles composed of slower motor units (43), and similar findings have been previously reported in the Actn3 - KO mouse (40).

Previous studies have reported an increase in fatigue resistance in EDL muscles following genetic manipulation of Actn3 (40) and Pgc - 1α (41), although differing fatigue protocols preclude direct comparison with the current data in the IL - 15Rα — KO mouse.

In a report of the study's findings, published in the Journal of the American Medical Association on March 6, researchers compared professional pest management treatments plus education with education alone and found no significant differences in asthma symptoms or mouse allergen exposure between the two groups.