Sentences with phrase «mouse tumor rejection»
Pramod Srivastava and Lloyd J. Old identify the human homologue of the mouse tumor rejection antigen gp96.
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Key studies in mice showed that NF - κB can mediate immune rejection of tumors.
«Although both anti-CTLA-4 and anti-PD-1 improved tumor rejection, mice treated with anti-CTLA-4 exhibited superior tumor control, suggesting the memory T - cell response by this agent is more durable,» said Allison.
The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit improved tumor control relative to DGKζ − / − mice.
James P. Allison and Matthew Krummel demonstrate that a monoclonal antibody directed against the CTLA - 4 molecule in a mouse model of melanoma could result in the rejection of tumors and that this rejection also resulted in immunity to a second exposure to tumor cells.
We observed enhanced tumor rejection in DGKζ - deficient mice and DKO mice relative to WT or Cbl - b — deficient mice.