Mouse vocalizations are also used as a model system in research into neuropsychiatric disorders such as autism.
Using these parameters to evaluate
mouse vocalizations, researchers were able to identify stuttering mice over a 3.5 - minute period.
«
Mouse vocalization is extremely rich and complex, but it's poorly understood partly because most of it is too high — it's ultrasonic,» says Drayna.
Not exact matches
As expected, the
mice carrying the mutated gene had far fewer
vocalizations, with longer gaps between «speech» compared with their unmodified littermates — Gnptab mutant
mice had about 80
vocalizations compared with 190 in the nonmutant
mice.
Scientists have assumed these tunes are hardwired in their tiny
mouse brains and doubted that rodents modify their songs after hearing others — a cognitive feat similar to
vocalizations by birds and some mammals, including dolphins, bats and humans.
Scientists at this year's Society for Neuroscience Conference in Chicago, Illinois, show that
mice, too, can stumble in their
vocalizations.
Mice usually sing to each other through a kind of song called ultrasonic
vocalizations, which are too high - pitched for a human to hear.
The researchers played back these ultrasonic
vocalizations to the
mice after they had activated the motor cortex and found that the neurons became much less responsive to the sounds.
«Rats and
mice, the most common lab animals, can't tell us much about speech disorders, since their
vocalizations are innate, not learned.
In previous work, Anderson's team demonstrated that
mice engineered with extra copies of the UBE3A gene show impaired sociability, as well as heightened repetitive self - grooming and reduced
vocalizations with other
mice.
This year molecular biologist Wolfgang Enard of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, explored that possibility with an extraordinary experiment: He inserted the human version of FOXP2 into
mice and studied the effects on the creatures» brains and
vocalizations.
The
mice also displayed features consistent with autism spectrum disorder, such as social interaction abnormalities, repetitive behaviors, and abnormal «squeaks» or
vocalizations.
The songs that
mice form with these ultrasonic
vocalizations (USVs) differ not only in the sequence of sounds, but also in their duration and complexity.
The scent of a female
mouse, for example, can be enough to trigger
vocalization in males.
How wild house
mice use their
vocalizations, however, remains largely unresearched.
Dr. Jarvis and colleagues report the results of their investigation into the effect of a genetic mutation in the Forkhead box protein # 2 (FOXP2) on the
vocalization patterns of adult male
mice.