Sentences with phrase «mtdna haplotype»

Among individuals with two divergent mitochondrial haplotypes (mt - haplotypes), the genome - wide analyses revealed significant differences in nuclear allele frequencies.

Indeed, he notes, it's improbable that all of the previous genetic studies of red deer, including those living throughout Europe today, wouldn't have picked up any of the haplotypes he and his team identified in their new research.

Possibly more telling, the deer found on the Outer Hebrides don't sport the haplotypes found on the Scottish mainland or on the isles of the Inner Hebrides (which are within swimming distance of the mainland, Stanton notes).

All 10 of the novel haplotypes were found on the outer Scottish islands.

All three teams found sections of DNA — haplotypes — that differed and ultimately pinpointed a single - letter difference that changed the amino - acid content of complement factor H. HapMap researchers say that refining the map further will speed up such discoveries, and they plan to release a new version this month that will include 4 million single - nucleotide variants.

The $ 138 million HapMap denotes haplotypes, stretches of DNA that are inherited together as unbroken blocks and can be identified by just a handful of DNA markers known as SNPS (single nucleotide polymorphisms).

Genetic tools still under construction, such as a haplotype map that will be used to discern genetic variation behind common diseases, could further accelerate the search for disease genes.

Intriguingly, the new genetic resistance locus lies within a region of the genome where humans and chimpanzees have been known to share particular combinations of DNA variants, known as haplotypes.

(Previous studies have shown that haplotype patterns differ in part based on ancestry.)

After months of passing the hat among countries and private companies, the U.S. National Institutes of Health (NIH) announced today that it has garnered the $ 100 million the 3 - year effort to construct a so - called haplotype map is likely to cost.

So called «matching haplotypes» could prevent the dangerous effect.

Large blocks of DNA, called haplotypes, are thought to come in only a handful of variants.

Persons B and D share a haplotype unlike the other three, characterized by three different DNA bases.

Efforts include the National Institutes of Health Diabetes Genome Anatomy Project and another NIH - sponsored venture, the International HapMap Project, which is creating a map of regions in the human genome called haplotypes, where the underlying DNA influences common diseases like diabetes.

«For instance, the benefits of the new UK10K haplotype reference panel are already being realised in analyses of international consortia as well as the 0.5 M people UK BioBank study.»

In response, Page and colleagues devised what is known as SHIMS (single - haplotype iterative mapping and sequencing) to establish a definitive reference DNA sequence of the Y chromosome.

Kere, now at the Karolinska Institute in Stockholm, Sweden, and his team found that, among these Finns, seven haplotypes cropped up in the stretch of chromosome 7.

To make certain these haplotypes weren't unique to Finns, Kere teamed up with Thomas Hudson, a haplotype expert at McGill University in Montreal, Canada.

By linking the Y chromosome lineages with genealogical information derived from written records, the researchers say it's now possible to define Y haplotypes for certain founder stallions.

Apart from a few private Northern European haplotypes, all modern horse breeds included in the study clustered into a roughly 700 - year - old haplogroup, transmitted to Europe by the import of Oriental stallions, they report.

The hazardous haplotypes appeared to boost asthma risk up to 2.5-fold.

«Many Y - chromosome haplotypes co-existed within Scythian horse populations.

During the same time period, reproductive management has involved an increasingly reduced number of stallions, up to the point that, today, almost all domesticates virtually carry the same, or highly similar, Y - chromosome haplotype (s).

The D1 haplotype likely developed after early humans moved into the area from elsewhere in Asia.

The new money should spur collaborations between scientists from Canada and other countries; the haplotype map project, for example, also involves significant contributions from the United States and the United Kingdom.

This process, known as amplicon resequencing, allows for each PCR amplicon to be sequenced individually, enabling both the identification of rare variants and the assignment of haplotypes.

So when we find the same haplotypes [blocks of DNA sequence around the gene] in Quebec, we are proving the common European root.

The joint US and Australian research team has now generated the first haplotype - resolved genome sequences for the rust fungi causing oat crown rust and wheat stripe rust diseases, two of the most destructive pathogens in oat and wheat, respectively.

When we noticed a big region with special pattern on the haplotype figure of chromosome X, we knew something must be there.»

Two haplotypes (genetic variants) of the Cytochrome Oxidase Type I sequence were detected: the «World haplotype» found in France, New Caledonia, French Polynesia, Singapore, Puerto Rico and Florida; and the «Australian haplotype» found in Australia.

Notably, an exceptionally large (14 Mb) and low - recombination region on the X chromosome appeared to have two distinct haplotypes in the high - and low - latitude populations, which may be possibly responsible for adaptations to cold and hot environments respectively.

The only locality with both haplotypes was in the Solomon Islands.

This suggest that two haplotypes exist in the area of origin of the species, but that only one of the two haplotypes (the «World haplotype») has, through human agency, been widely dispersed.

Genome - wide association analysis comparing affected and unaffected PWC with the SOD1 mutation identified a haplotype within the gene «SP110 nuclear body protein'that was associated with increased risk of developing DM and early age of onset.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

Often — but not always — a haplotype will point toward a more specific geography, like Japan or southern India.

These patterns are known as haplotypes, and sets of similar haplotypes are organized into haplogroups.

The research team, co-led by Dr Rollins and Professor Bill Sherwin of UNSW, in collaboration with the Department of Agriculture and Food in Western Australia, studied the DNA of 279 starlings near Munglinup in the south east of Western Australia and identified birds with a novel mitochondrial genome sequence (Haplotype H).

To study natural selection, the team combed the International Haplotype Map for long stretches of DNA flanked by a single nucleotide polymorphism (SNP, or «snip»)-- that is, an altered base, or «letter,» in the genetic alphabet.

«We also showed haplotype H was associated with a reduction in the number of copies of the mitochondrial DNA in cells, which might indicate that mitochondria in those cells are more efficient,» Professor Sherwin said.

Professor Sherwin, of the UNSW School of Biological, Earth and Environmental Sciences, said the advantageous mutation then spread rapidly through the population, with the proportion of birds carrying Haplotype H increasing from 17 per cent to 47 per cent during the five years of the study.

The process is slow, but geneticists may be able to create arrays of hundreds of such ultrasensitive tips working in parallel to carry out ultrafast haplotyping, Lieber says.

Right now, researchers must haplotype by analyzing genetic material from large families, or in their absence track gene frequencies in lots of individuals, a statistical process that is «prone to error,» says geneticist Andrew Collins of Southampton University in the United Kingdom.

The process of figuring out which of these genetic differences lie on each chromosome is called haplotyping, and it's an important step toward identifying which version of a gene may cause disease.

Positively selected haplotypes of EGLN1 and PPARA were significantly associated with the decreased hemoglobin phenotype that is unique to this highland population.

Haplotype - resolved information for the human genome is essential for understanding the relationship between genotype and phenotype.

In the study, researchers applied the pipeline to sequence the genome of an Asian individual (YH) and generated a 5.15 Gb assembled genome with a haplotype N50 of 484 kb.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

In 2010, Lo showed that with both parents» haplotypes known, it would be possible to predict the child's genome from the DNA in an expectant mom's blood.