To find out, the team looked at several hundred human
mu opiate genes, lumping together their own studies of several dozen volunteers from pain or opiate addiction clinics with studies from other labs.
Knockout mice, which completely lacked the gene and so manufactured
no mu opiate receptors, were all the more sensitive.
In their initial round of experiments, the group compared stretches of
the mu opiate gene in eight different strains of mice.
PET scans have demonstrated that some individuals have twice as many
mu opiate receptors in certain brain regions as others.
Uhl and his colleagues, Ichiro Sora and Zaijie Wang, of Johns Hopkins University and the National Institute on Drug Abuse (NIDA) zeroed in on the gene encoding
the mu opiate receptor — sections of which they first identified a decade ago.
Not exact matches
The most popular «narcotic» drug for dogs, Tramadol, is a synthetic that has «
opiate - like»
mu - receptor properties and activity [8].
Buprenorphine, an
opiate, is a
mu receptor.