Sentences with phrase «mu opioid»

Buprenorphine is a partial mu opioid agonist.

«The results of this study,» the authors wrote, «provide support for the hypothesis that endogenous and / or exogenous opioids, acting via the mu opioid receptor, may influence cancer outcomes.»

They suggest a possible therapeutic role for mu opioid receptor antagonists on cancer growth and metastasis, but caution that «there are no clinical trials in humans demonstrating a direct effect.»

Laboratory research from the University of Chicago Medicine and a genetic study from the University of North Carolina Medical Center both argue that the mu opioid receptor plays an important role in tumor progression and support a therapeutic role for opioid antagonists.

«Our findings,» they conclude, «suggest the mu opioid receptor may be a therapeutic target.»

Tumors did not grow in mice that lacked the mu opioid receptor.

Meanwhile, a drug that works much the same way — by blocking the beta - arrestin2 pathway while activating the G protein pathway at the mu opioid receptor — is currently in the final stages of human clinical trials.

These drugs kill pain largely by binding to the brain's mu opioid receptors, as they are called.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

Now, the researchers are trying to find molecules that can activate mu opioid receptors while blocking delta receptors.

Bohn and colleagues figured out that mu opioid receptors — the type of opioid receptor targeted by most drugs — send two different streams of messages.

«Opioids have both analgesic and rewarding effects and they have these effects through mu opioid receptors and these receptors are expressed in pain terminals in the spinal cord and in areas of the brain that regulate pain but are also expressed in areas that regulate reward and a sense of pleasure,» Boyle said, referring to cells found in a person's central nervous system that bind to naturally occurring opioid compounds and reduce pain and make people feel much better.

The chemicals in both bind to the mu opioid receptor in the brain.

Not exact matches

As it turned out, subjects who experienced the largest change in the mu - opioid system between the placebo injection and the painful one tended to report the least pain.

Using a small amount of a radioactive substance as a tracer, the scientists focused on the brain's mu - opioid system in which chemicals called endogenous opioids bind to receptors and hinder the spread of pain messages in the brain.

They controlled the experimental conditions so that the subjects experienced similar levels of pain, but found that individuals showed different patterns of mu - opioid activity.

«That implies that the mu - opioid receptor is somehow involved in tumor progression.»

The key actors here likely are mu - opioid receptors, molecules on cell membranes that allow opioids to bind to them and interact with the cell itself, he says.

Opioids block pain by binding to «mu - receptors» in the brain.

They were pioneers in showing that the brain's natural «painkiller» system — called the mu - opioid system — responded to pain when patients got a placebo.

Recent human studies have specifically found that a partner's presence can reduce pain, and supportive touching such as hugging is linked to activation of mu - opioid receptors in the brain.

For example, Young's research shows normally monogamous prairie voles do not develop pair bonds with their mates if their mu - opioid system is blocked; other studies have found that mice genetically engineered to have no mu - opioid receptors do not prefer their mothers to other mice the way normal baby mice do.

When a social bond is formed, oxytocin reconfigures the mu - opioid system so that a loved one's presence relieves stress and pain — and that person's absence, or a threat to the relationship, increases distress.

This paper did not measure mu - opioid receptor binding, but other work with humans strongly suggests it is involved.

Those naturally produced opioids, and the opioid drugs that imitate them, inhibit pain by acting on three kinds of opioid receptors — mu, kappa and delta — that are found on the outside of nerve cells in the brain, spinal cord, digestive tract and elsewhere.

Effects of defeat stress on behavioral flexibility in males and females: Modulation by the mu - opioid receptor.

But it's the mu receptor that is primarily responsible for opioids» analgesic effects, and drugs that fit it snugly launch a cascade of chemical changes in nerve cells that slow down the transmission of pain messages to the spinal cord and the brain.

Opioids work to activate this pathway via the mu receptor, and decrease the signal coming in from the painful site.

Wang D, Sun X, Sadee W. Different effects of antagonists on mu -, delta -, and kappa - opioid receptors with and without agonist pretreatment.

Regulation of human affective responses by anterior cingulate and limbic mu - opioid neurotransmission

Variation at the mu - opioid receptor gene (OPRM1) influences attachment behavior in infant primates