Purebred dogs have
much smaller gene pools, which can lead to serious medical problems.
In general, pedigree breeds use
a much smaller gene pool for breeding than domestic cats and therefore have a higher risk of developing inherited disorders.
Not exact matches
Leaving aside the fact that none of these folks look like they belong in the same
gene pool (and The Wire has a funny article about how only one of the actors in the film is actually Jewish), the premise has promise, since forcing the members of a dysfunctional family (and there is
much «dys» here) to spend time in a
small space could lead to some funny results.
The gradual loss of alleles from populations is known as «genetic drift», this is a random process which occurs naturally in all populations; it may not matter
much in the large
gene pool of a large population, but becomes increasingly serious over time in the
small gene pools of
smaller populations.