By conducting an RNA - sequencing experiment of 103 matched tumour and normal colon
mucosa samples from Danish CRC patients, 90 of which were germline - genotyped, researchers from the collaborative European project SYSCOL show that both inherited and acquired mutations in non-coding regions of the genome also contribute to cancer development and progression (Linda Koch, Nature Reviews Genetics).
Not exact matches
The current study differs from previous reports in that intestinal swabs, which provided a direct method of looking at specific areas of the intestinal
mucosa, were studied instead of only relying on stool
samples.
Gb3 expression in nondiseased gastric
mucosa was restricted to chief and parietal cells at the bottom of the gastric glands, and was not elevated in endoscopic
samples of gastritis (n = 10).
By assessing the permeation of water - soluble molecules lactulose and mannitol through the intestinal
mucosa after testing a urine
sample collected after the drink, accurate information is obtained regarding the integrity and function of the lining of the small intestine.
Since the biopsy procedure only
samples the
mucosa it is possible to miss detecting a tumor that involves only the deeper layers of the intestinal tract.