Sentences with phrase «multicenter trial»

A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetes.

In a large, multicenter trial conducted in the United Kingdom, 7 or 10.5 g / d of psyllium was provided to 340 patients with mild to moderate hypercholes - terolemia over 12 weeks (MacMahon and Carless, 1998).

In a multicenter trial with 394 individuals, psyllium improved bowel function better than other laxatives (mainly lactulose), with superior stool con - sistency and decreased incidence of adverse events (Dettmar and Sykes, 1998).

A multicenter trial was conducted to test whether fructooligosaccharides worsen gastrointestinal symptoms in people with irritable bowel syndrome (Olesen and Gudmand -

The largest intervention study on a vegan diet that I know of showed better overall nutrient intake, but calcium was one nutrient that was very low Nutrient intake in the GEICO multicenter trial: the effects of a multicomponent worksite intervention.

Study of the ketogenic agent AC - 1202 in mild to moderate alzheimer's disease: A randomized, double - blind, placebo - controlled, multicenter trial.

The Australian multicenter trial of growth hormone (GH) treatment in GH - deficient adults.

In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat).

«Double - blind, multicenter trial comparing acetyl l - carnitine with placebo in the treatment of fibromyalgia patients.»

Study of the ketogenic agent AC - 1202 in mild to moderate Alzheimer's disease: a randomized, double - blind, placebo - controlled, multicenter trial.

Primary analysis of a phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T - VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB - IV melanoma.

This double - blind multicenter trial enrolled 282 patients with advanced colorectal cancer for whom all available standard therapies had failed.

A new multicenter trial focuses on providing precision treatments for rare cancers based on genetics, not tumor site.

Endocrinologist Robert Rizza of the Mayo Clinic in Rochester, Minnesota, welcomes the verification of the deCode study, praising the size of the multicenter trial.

As the next step for this line of research, the investigators plan to expand to a larger prospective multicenter trial to further investigate the efficacy of the treatment in a larger sample of patients with dry AMD.

The multicenter trial involving 100 patients showed that the addition of ipilimumab to nivolumab, which is currently FDA - approved for treatment of kidney cancer, leads to responses that can last beyond two years.

The CoreValve US Pivotal was a prospective, non-randomized single - arm, multicenter trial to determine the safety and efficacy of self - expanding TAVR at two - years in patients at extreme risk for surgery.

We have just started a multicenter trial using simvastatine to reduce inflammation in the brain of patients with schizophrenia.

In a recent study analyzing the results of a global, multicenter trial, data show a 91 percent probability of favorable stroke outcome if patients» blood flow was restored within 150 minutes of stroke.

«If our results are confirmed in a large multicenter trial,» Dutta said, «vitamin D supplementation would provide us with a new tool in the armamentarium of diabetes prevention strategies.»

Vanderbilt - led research, as part of an international, multicenter trial, found regular blood transfusion therapy significantly reduces the recurrence of silent strokes and strokes in children with sickle cell anemia who have had pre-existing silent strokes, according to study results released today in the New England Journal of Medicine (NEJM).

The phase 1b multicenter trial included 21 patients on three continents, all of whom had metastatic melanoma.

A total of 2,129 patients with mild dementia due to Alzheimer's disease participated in the double - blind, placebo - controlled, phase 3 multicenter trial.

Results of this multicenter trial suggest that it is.

Altogether, 232 children with AML enrolled in the six - year, multicenter trial that ended in 2008.

Another more recent study assessed the efficiency of collagen peptides in a randomized, double blind, controlled multicenter trial, in which 250 subjects with primary osteoarthritis of the knee were given 10g of collagen peptides daily.

The research team is planning larger, multicenter trials to confirm the role of subglandular ADC analysis in predicting preterm birth, Dr. Masselli said.

Previous multicenter trials, such as HORIZONS - AMI and EUROMAX, have demonstrated superiority of bivalirudin to heparin plus glycoprotein IIb / IIIa inhibitors (GPI), but a recent single center trial, HEAT - PPCI, demonstrated the superiority of heparin monotherapy over bivalirudin alone, with concern for an increased rate of stent thrombosis observed in bivalirudin - treated patients.

Large, multicenter trials are now the norm for clinical trials.

In order to make this work, the authors describe necessary steps of a rigorous informed consent process that outlines the risks and uncertainties, close involvement of institutional review boards, and multicenter trials to collect data.

He is the lead investigator of the NICHE and E-FIT Multicenter Trials on navigated brain stimulation for upper limb recovery after stroke.

She has published extensively, leading national and international multicenter trials, has been featured in the «Best Doctors of America» and has served on several national and international committees.

Tamoxifen may not be right for older women You can expect to take any of these drugs once a day for five years — although a 2007 study in the journal Cancer suggests that tamoxifen may be on its way out for breast cancer survivors who've passed menopause: Two multicenter trials found that when women who'd been taking tamoxifen for two or three years switched to an AI, their survival rates significantly improved compared with continuing on with tamoxifen.

Not exact matches

Floating Hospital's Division of Newborn Medicine has a longstanding history of participation in multicenter clinical trials and NIH - funded clinical investigation.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

The researchers conducted a randomized, multicenter, clinical trial that included 1,000 Chinese women with PCOS at 21 sites in China.

Promising results of an earlier, initial, multicenter clinical trial of nivolumab, first reported in 2013 and directed by Brahmer, led to the current phase III trial of 260 patients treated at hospitals across the world.

Loyola participated in a pivotal, multicenter clinical trial of the pressure - sensing catheter.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

Outcomes of children and young adults with cancer have improved, primarily due to enhanced understanding of tumor biology and due to the clinical application of biological discoveries through multicenter clinical trials.

The attendees developed a list of top research priorities and a research agenda for exercise in solid organ transplant, which includes the need to conduct large multicenter intervention studies, standardize measures of physical function in clinical trials, examine the benefits of novel types of exercise, and assess the effects of exercise on measures such as immunity, infection, and cognition.

An analysis of diagnostic test results from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial — in which patients with stable chest pain were randomized to either anatomic or functional testing as an initial diagnostic strategy — showed that the presence and extent of coronary artery disease detected by CT angiography better predicted the risk for future cardiac events than did measures of exercise tolerance or restricted blood flow to the heart muscle.

The study is believed to be the first and largest, multicenter, double - blind, randomized controlled trial of its kind to investigate the use of sublingual immunotherapy against ragweed allergy.

Researchers at Mount Sinai and in the European Union conducted two multicenter, randomized, double - blind, placebo - controlled trials of subcutaneous implants containing afamelanotide.

Results of a multicenter phase 1 clinical trial presented today at the 2015 San Antonio Breast Cancer Symposium show that the anti-androgen agent enzalutamide is active and well - tolerated alone and with fulvestrant in patients with advanced breast cancer.

The first multicenter CTL019 trial has recently opened in the U.S., and additional multisite trials are expected to initiate by the end of the year.

Doraiswamy added that the findings provide support for planned and ongoing multicenter clinical trials of asymptomatic older adults with plaque - positive scans.

It is the first time that a gene therapy based on genetically modified stem cells is tested in a multicenter, international clinical trial that shows a reproducible and robust therapeutic effect in different centers and different countries.

Based on results from this and previous studies, pemetrexed and gemcitabine were included in a St. Jude - led multicenter clinical trial of children and adolescents newly diagnosed with medulloblastoma.

For very rare diseases such as WAS, multicenter clinical trials are the only effective way of proving the safety and efficacy of gene therapy and having it rapidly approuved and made available to all patients.