«A better understanding of how microtubule
dynamic instability is regulated could open new opportunities for improving the potency and selectivity of existing anti-cancer drugs, as well as facilitate the development of novel agents,» Nogales says.
Through a combination of high - resolution cryo - electron microscopy (cryo - EM) and a unique methodology for image analysis, a team of researchers with Berkeley Lab and the University of California (UC) Berkeley has produced an atomic view of microtubules that enabled them to identify the crucial role played by a family of end - binding (EB) proteins in regulating microtubule
dynamic instability.
Microtubules, hollow fibers of tubulin protein only a few nanometers in diameter, form the cytoskeletons of living cells and play a crucial role in cell division (mitosis) through their ability to undergo rapid growth and shrinkage, a property called «
dynamic instability.»
The dynamic instability that makes it possible for microtubules to transition from a rigid polymerized or «assembled» nucleotide state to a flexible depolymerized or «disassembled» nucleotide state is driven by guanosine triphosphate (GTP) hydrolysis in the microtubule lattice.
«One of the most interesting phenomena associated with microtubules is
this dynamic instability,» Kolomeisky said.
We applied this to systems spanning four orders of magnitude in space and time, including the diffusion of single transcription factor molecules in stem cell spheroids,
the dynamic instability of mitotic microtubules, the immunological synapse, neutrophil motility in a 3D matrix, and embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.
He received the Award of Excellence of the University of Heidelberg as well as the Otto - Haxel - Prize for his diploma work at the European Molecular Biology Laboratory (EMBL) on the «Analysis of microtubule
dynamic instability with light sheet - based microscopy».
This work examines how the carboxy - terminal tail domain of β - tubulin governs microtubule
dynamic instability and the structure of plus ends using complementary in vivo and in vitro experiments.
The front and rear ends complement each other rather than conflict, with just enough
dynamic instability in the tail to be able to get the car turned in with a mild lift of the throttle.
For cyrosphere, the team will examine the near - term risks of initiating
the dynamic instability and onset of the collapse of the Antarctic Ice Sheet due to rapid melting by warming waters adjacent to the ice sheet grounding lines.
Not exact matches
The end result is a
dynamic that wards off further
instability / uncertainty.
Buchler criticizes what others have singled out as the relevant ontological differences: «being and becoming,» «permanence and change,» «the static and the
dynamic,» «stability and
instability,» «determinateness and indeterminateness.»
To combat this
instability, the shoulder joint is equipped with structures to provide secondary stability, often referred to as static and
dynamic stabilizers.
The award cited his dissertation, «For developing a novel laboratory platform to investigate the magnetohydrodynamic
instabilities that drive solar eruptions, and for discovering a new failed eruption regime where the torus
instability is halted by a
dynamic tension force.»
The more
dynamic picture in the new simulations suggests that the rate of change in the first half of this century — which does not involve a significant contribution from processes like marine ice - cliff
instability, or hydrofracturing — is essentially uncorrelated with the rate of change later in the century.
RBT ™ takes all the benefits of traditional bodyweight training exercises and adds
instability, rotation and
dynamic tension to challenge your balance and core.
Faster steering and counter steering during an evasive maneuver results in less vehicle
instability, supported by
Dynamic Stability Control (DSC).
Instead, VDIM anticipates vehicle
instability in virtually any direction and makes stabilizing corrections while allowing higher
dynamic capability.
With modern society being more
dynamic than ever and children changing locations, schools and family units more frequently (Walsh 2003), it is increasingly important to consider the protective role that companion animals can play in reducing the negative effects associated with these
instabilities.
Note that such an ice
dynamic uncertainty was only included for Greenland but not for Antarctica;
instability of the West Antarctic Ice Sheet, a scenario considered «very unlikely» in the TAR, was explicitly not included in the upper limit of 88 cm.
... Most projections for the Antarctic Ice Sheet since IPCC AR5 limit the sea - level contribution as a result of
dynamic discharge and the potential onset of the marine ice sheet
instability to 0.3 m by the end of this century.
The more
dynamic picture in the new simulations suggests that the rate of change in the first half of this century — which does not involve a significant contribution from processes like marine ice - cliff
instability, or hydrofracturing — is essentially uncorrelated with the rate of change later in the century.
The experiment would be the first fully coupled global simulation to include
dynamic ice shelf — ocean interactions for addressing the potential
instability associated with grounding line dynamics in marine ice sheets around Antarctica.
Options like Systematic Transfer Plan and
Dynamic Fund Allocation help in safeguarding investments against market
instability.
Two concepts capture the
dynamic and complex nature of contemporary family structure: family
instability and multipartner fertility.
Their paper and presentation titled, Family
Instability, Multipartner Fertility and Behavior in Middle Childhood, looks at two concepts in family demography that capture the dynamic and complex nature of family structure, family instability and family
Instability, Multipartner Fertility and Behavior in Middle Childhood, looks at two concepts in family demography that capture the
dynamic and complex nature of family structure, family
instability and family
instability and family complexity.
Minimizing the DV or child abuse allegations, the family
dynamic proponents are likely to blame mothers for exaggerating their abuse allegations, not emphasize the anger that victims feel (indeed, they treat it as a weakness and possibly an indication of
instability and poor parenting), and assume that mothers raise abuse allegations to alienate their children from their other parent.