Sentences with phrase «multidrug resistance gene»

In herding breeds of dogs there is a defined mutation called MDR1 - 1 ∆ (multidrug resistance gene), also called ABCB1, which affects P - glycoprotein function.

These drug sensitivities result from a mutation in the multidrug resistance gene (MDR1 gene.)

Signs of ivermectin toxicosis can occur in any breed but are most common in ivermectin - sensitive breeds such as collies and other herding breeds.20, 21 Ivermectin sensitivity is derived from a frameshift deletion mutation of the multidrug resistance gene (MDR1; the most recent nomenclature is ABC ±), resulting in a severely truncated, nonfunctional protein product.

ABSTRACT: A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage.

The expression of the tumoral multidrug resistance gene (MDR1), which encodes P - glycoprotein, and NANOG, a stem - cell marker and a regulator of the expression of drug resistance genes, was determined using qRT - PCR.

In addition, they observed that parasites with multiple copies of the multidrug resistance gene pfmdr1 tended to be less susceptible to several drugs, including DHA.

Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P - glycoprotein.

Multidrug resistance genes and p - glycoprotein in the testis of the rat, mouse, Guinea pig, and human

Not exact matches

One of the newest banes of U.S. medical centers, a supervirulent and multidrug - resistant strain of Acinetobacter baumannii, likewise appears to have picked up most of its resistance in gene swaps with other species.

When multidrug - resistant malaria was detected, researchers were initially handicapped by the lack of a marker for piperaquine resistance; now, they have one, the presence of multiple copies of the plasmepsin 2 gene.

We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.

«And this approach could be used in conjunction with high - throughput screening techniques to identify gene sets associated with problems such as multidrug resistance or benefits, like those related to probiotics.»

Prevention of multidrug resistance (MDR) should be a future target, possibly with inhaled gene therapy for lung cancer.

Treatment with MIA - 602 lowered the level of growth hormone - releasing hormone and growth hormone - releasing hormone receptors and significantly reduced the expression of multidrug resistance (MDR1) gene and the drug resistance regulator NANOG.

Therefore, these reference genomes can also enable further studies, such as identifying gene expression changes that explain multidrug resistance and host interaction.

Conditional essentiality of individual genes to antimicrobial resistance was evaluated in an epidemic multidrug - resistant clone of K. pneumoniae (ST258).

Mutations in ABCC2, also known as the multidrug resistance — associated protein 2 gene, associate with Dubin - Johnson syndrome.

A recent study by Dr. Katrina Mealey has identified that the problem of drug sensitivity relates to a genetic mutation in the multidrug - resistance gene (MDR1).

The phrase «multidrug resistance mutation 1 (MDR1)» refers to a specific mutation that can occur at a gene known as the MDR1 gene, also known as the ABCB1 gene.

In 2001, Katrina Mealey, DVM, PhD, discovered that collies and other dogs with herding - breed heritage have a defect in the MDR1 (multidrug resistance 1) gene.1 The nomenclature for the MDR1 gene also includes the designation ABCB1 gene (adenosine triphosphate — binding cassette transporter).