Sentences with phrase «multiple animal models»

Neurona's founders have discovered that certain types of neuron transplants can rebalance nervous system activity, repair neural circuits, and rescue multiple animal models of disease.

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

«We found that AIM2 inhibits tumorigenesis in multiple animal models of colorectal cancer by restricting the pro-survival signaling molecule, Akt, which is commonly hyperactive in many human cancers.»

Not exact matches

In the lab, researchers will try to re-create the Thai results in monkeys to validate a new animal model using multiple low doses.

His laboratory already has shown that by inhibiting calcium channels in T - cells, they were able to prevent T - cell activation in animal models of autoimmune diseases like multiple sclerosis and colitis.

An FDA - approved drug for high blood pressure, guanabenz, prevents myelin loss and alleviates clinical symptoms of multiple sclerosis (MS) in animal models, according to a new study.

«Blood pressure drug protects against symptoms of multiple sclerosis in animal models.»

«In less than a year, our group and others have demonstrated that multiple vaccine platforms can provide robust protection against Zika virus challenge in animal models.

The researchers then tested the capacity of the modified cells to kill human multiple myeloma cells in laboratory studies and an animal model.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.

IRTA has also developed multiple animal and / or arthropod models to work with zoonotic pathogens such as avian and swine influenza, RVFV, MERS - coronavirus, West Nile virus and chikungunya virus.

Animal gait is affected in models of human disorders such as Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, spinal cord injury and many others.

The model is the first to focus on how and why home ranges expand or contract in territorial animals, a trend noted in multiple animals ranging from deer and pandas to owls and flying lizards.

An animal model of cortical and callosal pathology in multiple sclerosis.

The lab has examined MRI cell tracking in animal models of dysmyelination, multiple sclerosis, brain tumors, spinal cord, stroke, and diabetes.

These exosomes contain specific microRNAs that promote myelination of aging brain as well as brain damaged by multiple sclerosis modeled in animal brain tissues.

Graber will also lead the development of the Comparative Models of Regeneration Database (RegenDB), a novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug therModels of Regeneration Database (RegenDB), a novel bioinformatics resource supported by the National Institutes of Health (NIH) whose function is to integrate gene function across multiple animal, tissue and cell models in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug thermodels in order to validate and inform the hypotheses needed for the discovery and development of regenerative medicine drug therapies.

Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi CR, Westerberg G, Marsh JL.A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease..

We have discovered multiple genes critical for generating liver and pancreas cells and have created novel animal models for diseases such as diabetes and Alagille Syndrome.

By targeting antigens to B cells using monoclonal antibodies, he successfully inhibited the development of multiple sclerosis in an animal model.

3/21/2007 Inhibiting Blood to Save the Brain UCSD researchers suppress relapsing paralysis in mouse model of Multiple Sclerosis A fibrous protein called fibrinogen, found in circulating blood and Fibrinogen (red) and activated microglia (green) in a brain lesion of an animal mode... More...

March 13, 2015 Blood pressure drug protects against symptoms of multiple sclerosis in animal models An FDA - approved drug for high blood pressure, guanabenz, prevents myelin loss and alleviates clinical symptoms of multiple sclerosis (MS) in animal models, according to a new study.

Berman faculty have led or served on committees of the National Academy of medicine related to human and to animal research and led work for the National Cancer Institute creating model national guidance on informed consent; Berman faculty have served on multiple Data Safety and Monitoring Boards for federally and privately funded trials including the recent NIH sponsored ebola trials.

Multiple studies show that the catechin compounds found in green tea can have various protecting effects on neurons in test tubes and animals models, potentially lowering the risk of disease like Alzheimer's and Parkinson's.

To date, the autoimmunes: Type 1 Diabetes, celiac disease and multiple sclerosis (in animal models) have been positively associated with intestinal permeability.

Multiple studies show that the catechin compounds in green tea can have various protective effects on neurons in test tubes and animal models, potentially lowering the risk of Alzheimer's and Parkinson's (28, 29, 30).