They say that the system can be constructed with more than five different aptamers, allowing detection of
multiple biomarkers at once.
Not exact matches
«Targeting
multiple biomarkers could potentially allow us to identify prostate cancer
at its early stages as well as after metastasis in one scan.»
We will develop multiplexed assays that will allow us to measure
multiple proteins
at a time in human samples, thus increasing the speed with which we can test candidate
biomarkers.
«Using innovative data normalization and gene selection approaches, we combined the statistical power of
multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic
biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine
at HMS.
«Our group, which includes more than 180 myeloma researchers worldwide, has updated the definition of
multiple myeloma for diagnostic purposes to include validated
biomarkers in addition to the current clinical symptoms used for diagnosis which include, elevated blood calcium levels, kidney failure, anemia and bone lesions,» said lead author S. Vincent Rajkumar, M.D. a hematologist
at Mayo Clinic.
The research ideas you develop
at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise
biomarkers with high specificity for cancer or even for
multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease
Analysis shows that looking
at multiple biomarkers to predict progression is not only mathematically possible, it improves upon methods using single
biomarkers.