Patients may also be less likely to develop resistance to immunotherapy because of the immune system's ability to target
multiple cancer antigens simultaneously, and adapt to changing cancer cells.
The Cancer Vaccine Collaborative is working on treatments that target
multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.
Not exact matches
After being infused back into patients» bodies, these newly built cells both multiply and seek out a peptide expressed by the
antigens NY - ESO - 1 and LAGE - 1 found in
multiple myeloma
cancer cells.
Richard Vague, the event's honorary chair, took the podium to acknowledge the vast achievements of the ACC, as did Lori Alf, a
multiple myeloma patient of Edward Stadtmauer, MD, chief of Hematologic Malignancies, whose
cancer is in remission after receiving chimeric
antigen receptor (CAR) therapy.
«We have created a potentially much less expensive approach to making a therapeutic
cancer vaccine that, while targeting a single tumor
antigen, generates an immune response against
multiple antigens.
In addition, because ZVex product candidates have the potential to carry the genetic material of different tumor
antigens, as well as immunostimulatory molecules, we can design them to target
multiple types of
cancers.
The new results — from trials for patients with advanced lymphoma,
multiple myeloma, and pancreatic
cancer — expand on Penn's work with chimeric
antigen receptor (CAR) therapies, building on findings in patients with chronic lymphocytic leukemia and acute lymphoblastic leukemia dating back to the start of the first clinical trial in 2010.