«The loss or gain of
multiple cancer driver genes that individually have low potency can add up to have big effects,» he said.
Not exact matches
If metastatic
cancers are most often made up of cells with different genetic
drivers, perhaps researchers should be targeting the primary tumor with
multiple drugs to contain the
cancer.
The task is large but not insurmountable, says Rebecca: «One of the big problems with this
cancer is that it doesn't have a recurrent
driver gene — it's a disease dominated much more by
multiple tumour suppressor genes being lost.
Careful examination of primary breast
cancers often reveals
multiple genomically distinct subclones that may contain
driver alterations that follow spatial patterns of segregation.