Sentences with phrase «multiple candidate genes»

Because the results of the as - yet few and relatively small - scale studies are not wholly consistent, there is a clear need for larger - scale and carefully designed studies that examine multiple polymorphisms of multiple candidate genes.

Not exact matches

In 2013, Soderling's group selected one of those gene candidates, Arp2 / 3, based on its importance in controlling the formation of synapses — the links between neurons — and its association with multiple neuropsychiatric disorders.

Some of the genetic factors that are being researched right now are multiple genes contributing to the disease (there are about a dozen genes that are leading candidates), and the possibility of epigenetic interactions (that is, certain genes and other biological molecules that determine whether and when certain genes present in the body are turned on or off) that may contribute to schizophrenia.

Cystic fibrosis may not be the most likely candidate for gene therapy, however, because the disease affects multiple organ systems.

Linkage and candidate gene studies have been highly successful in the identification of genes that cause the monogenic variants of diabetes and, although progress in the more common forms of T2D has been slow, a number of genes have now been reproducibly associated with T2D risk in multiple studies.

By sequencing the exomes of multiple individuals, isolating what we'd call «tier 1» variants — Nonsynonymous, nonsense, splice site, or frameshift - indel — and then removing all known common variants from public databases, Dr. Shendure and colleagues can reduce 20,000 gene candidates down to a handful.

Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult.

330/11: 15 Colocalization of eQTLs at WHRadjBMI GWAS loci with multiple association signals highlighted candidate functional genes for body fat distribution.