Sentences with phrase «multiple cell death»

Kanneganti emphasized that their discoveries have fundamental importance, because they identify a key innate immune sensor that recognizes the influenza virus and a regulator of multiple cell death pathways.

Not exact matches

There it directly targeted multiple oncogenes at once, increasing cancer cell death and reducing cancer cell growth.

Now, two new studies have added another disease: multiple sclerosis (MS), an autoimmune disorder that strips away nerve cells» protective covers, leading to muscle weakness, blindness, and even death.

Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell - survival proteins (survivin, Mcl - 1, XIAP or cIAP2).

Dor's own group reports this week that its technique for tracing the origin of circulating DNA detected the expected type of cell death in people with pancreatic cancer, type 1 diabetes, multiple sclerosis, and brain injuries.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

Syndax Pharmaceuticals, Inc. («Syndax,» the «Company» or «we»)(Nasdaq: SNDX), a clinical stage biopharmaceutical company developing entinostat and SNDX - 6352 in multiple cancer indications, in collaboration with The Wistar Institute and Indiana University Melvin and Bren Simon Cancer Center, today announced the publication of a preclinical report demonstrating that entinostat, Syndax's oral, Class - I histone deacetylase inhibitor, enhances the antitumor effect of PD - 1 (programmed death receptor - 1) blockade through the inhibition of myeloid derived suppressor cells (MDSCs).

By taking out these survivor genes, the assassin molecule activates multiple death cell pathways in parallel.

Animal studies have shown that lengthy or multiple experiences with anesthesia can lead to cell death and problems with the formation of connections among brain cells.

Multiple mutations in DNA — specifically, abnormalities in the p21 and p53 genes, among other changes — stop the process of apoptosis, or programmed cell death, that normal cells undergo.

On the one hand, it regulates progression from premalignancy to malignancy, most likely by preventing oxidative stress - induced death of HCC - initiating cells, thereby allowing such cells to accumulate multiple oncogenic mutations, while promoting their growth through mTORC1.

As the investigators note, the rapid age - related arterial stiffening and cardiac arrhythmias that appear to be at cause for the majority of deaths in BubR1H / H mice were not attenuated by ablating p16Ink4a - expressing senescent cells — but these tissues had little burden of such cells, so this finding reinforces the conclusion that the multiple aging phenotypes arrested in these mice when senescent cells were ablated is attributable specifically to the removal of their baleful influence on local tissues.

Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK Death of multiple myeloma cells induced by cAMP - signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584

Programmed cell death in plants: a pathogen - triggered response activated coordinately with multiple defense functions

Multiple levels of tobacco WIPK activation during the induction of cell death by fungal elicitins

December 14, 2015 Brain cell death is a possible trigger of multiple sclerosis Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Mmultiple sclerosis Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern MMultiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine.

Prior research had developed a number of new compounds making use of a novel drug discovery paradigm which begins with natural products extracted from plants; it then entails selecting synthetic derivatives which demonstrate efficacy in multiple assays testing protection against different factors of the nerve cell damage and death which take place in brain injuries and in age - associated neurodegenerative conditions.

Similar to the physical and cellular burn of exercise that creates some oxidizing free radicals, the «stress» from cruciferous vegetables stimulates our mitochondria to produce homemade antioxidants to counterbalance the oxidation and protect our vital DNA.28 Even cancer cells have caught on to this central role of our mitochondria — the bastards can amplify their levels of some of these same pathways — further stressing their importance for survival.25 However, our cells still seem to have the upper hand, as multiple studies show that the organosulfur chemicals in many of these anticancer vegetables can severely stress cancer cells, leading to oxidative damage, and ultimately, death.29

Multiple studies in laboratory's show that curcumin can reduce the growth of tumors, the spreading of cancer, and contribute to overall cancer cell death.

The result is an intense inflammatory reaction in the tissues where the virus - infected cells reside, which causes damage to multiple systems at once and ultimately leads to death.

Any time the seizures are too frequent they can cause a process call «kindling» in which further (non-epileptic) brain cells are affected adversely leading to the next set of seizures occurring even sooner or lasting longer.8 Eventually some dogs have very frequent clusters of seizures happening multiple time in one day, or go into a continuous seizure (status epilepticus) which is life threatening and can lead to permanent brain damage or death.