Human mesenchymal stem cells (hMSCs) are currently the most common adult stem cell type used for cell therapy applications due to their regenerative properties and ability to differentiate into
multiple cell lineages (adipocyte, chondro ¬ cyte, and osteocyte).
This latest study reports the generation of
multiple cell lineages of the eye, including the lens, cornea, and conjunctiva, using human induced pluripotent stem cells.
Not exact matches
She also investigates how asymmetric
cell division impacts on the cellular potential to give rise to
multiple lineages in vivo.
The existence of
multiple sub-states within a single ES
cell basin of attraction or
multiple interrelated attractors representing distinct
lineages could account for pluripotency.
While the small changes in
lineage transcription observed in our data set would be consistent with a stochastic model, the ES
cell model described in Figure 9 would require both cross-repression and additional positive feedback loops to drive these random changes in gene expression down
multiple distinct routes.
For example, assaying the genomes of
multiple cells during development reveals developmental
lineage trees - the kinship
lineage - whereas cellular transcriptomes inform us about the regulatory state of
cells and their gradual restriction in potency - the Waddington
lineage.
The epidermis is maintained by
multiple stem
cell populations whose progeny differentiate along diverse, and spatially distinct,
lineages.