Stem cells are ideal candidates for editing, as they are highly renewable and expandable, and they can differentiate
into multiple cell types.
PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present
in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.
«ADRCs consist of
multiple cell types with multiple potential benefits,» said Timothy D. Henry, MD, MSCAI, director, division of cardiology at the Cedars - Sinai Heart Institute and the study's lead investigator.
Intercellular adhesion molecule - 1 expression is required
on multiple cell types for the development of experimental autoimmune encephalomyelitis.
University of Chicago Medicine researchers have built a model system that
uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.
They, and other cancers, also exude a chemical signal that attracts stem cells — specialized cells that can
produce multiple cell types in the body.
The system, Soscia said, also enables researchers to go easily from the «macro world to the micro world,»
depositing multiple cell types in smaller areas than possible before.
In DM, an expanded triplet or quadruplet repeat produces toxic RNA, which disrupts the process of RNA splicing,
affecting multiple cell types and tissues.
«What needs to be done now is to make it robust and accurate,» says Clark, a steering - committee member of the International Human Epigenome Consortium, a bid launched in January to map the epigenome
in multiple cell types.
In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than
multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.
But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to
the multiple cell types that make up a live baby.
In this webinar, we will hear from experts about different ways to isolate and characterize specific cell populations, including the nephrogenic progenitors that give rise to mature functional renal cells and mesenchymal stem cells which can differentiate into
multiple cell types.
Research to create new lungs in the lab has lagged because of their complex structure and
multiple cell types, notes biomedical engineer Laura Niklason of Yale University.
What is there — a spinal cord, all major regions of the brain,
multiple cell types, signaling circuitry and even a retina — has the potential to dramatically accelerate the pace of neuroscience research, said Anand, also a professor of neuroscience.
Every body organ consists of tissue groups with
multiple cell types.
These cells are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate into
multiple cell types that occurs in tumors.
Svendsen's chip - brains have
multiple cell types and blood vessels like the real brain.
CSCs are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate into
multiple cell types that occurs in tumors.
Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into
multiple cell types.
In the study, the researchers compared how well CRISPRi and CRISPR - Cas9 silenced a particular gene that controls iPSC pluripotency — the capability of iPSCs to turn into
multiple cell types.
Like normal stem cells, cancer stem cells are thought to possess the ability to self - renew and differentiate into
multiple cell types.
It is suggested that some of these cells may be able to differentiate into
multiple cell types (called «plasticity» or «trans - differentiation»).
To determine whether rapamycin slows aging, we assessed a large number of structural and functional aging phenotypes in
multiple cell types, tissues, and organs systems in our aging mouse cohorts.