Sentences with phrase «multiple checkpoints in»

Players must die multiple times, across multiple checkpoints in order to trigger a perma - death.

Tip: Set multiple checkpoints in increments of 8 weeks.

Not exact matches

Speaking of checkpoint inhibitor drugs... Merck's star cancer immunotherapy treatment Keytruda is facing some troubling clinical trial incidents which have now compelled the Food and Drug Administration (FDA) to halt three studies of the drug in multiple myeloma, a rare blood cancer, after a number of patient deaths.

Wherry, together with his colleagues in the Parker Institute for Cancer Immunotherapy at Penn, are involved in multiple checkpoint - related trials, in melanoma, lung cancer, renal cell carcinoma, and others, including combining checkpoint blockade with radiation.

Emerging evidence shows that alterations in multiple signaling pathways are involved in primary and / or secondary resistance to checkpoint inhibition.

iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has demonstrated the same anti-tumour activity in multiple preclinical tumour models in combination with immune checkpoint inhibitors as competitors, but also has demonstrated superior brain penetration.

A promising avenue of clinical research in multiple myeloma is the use of immune checkpoint inhibitors.

EOS200271 has demonstrated anti-tumor activity in multiple preclinical tumor models in monotherapy and in combination with immune checkpoint inhibitors.

If approved by the FDA in October for the treatment of refractory melanoma, pembrolizumab would be the first PD - 1 checkpoint inhibitor approved in its class, beating out BMS's nivolumab in the race to the finish line — or starting line, really, since both drugs will likely have multiple future uses.

Several checkpoint inhibitors, targeting multiple different checkpoints, are currently in development.

The shift to multiple, bite - sized missions per locale vice the longer mission structure of the older games feels more in line with the mobile aspect of the game (although the lack of checkpoints within each mission can be an annoyance).

«The Cambridge Checkpoint exams, together with the progress checks, give schools, teachers, parents and pupils an educational diagnostic tool to monitor the educational progress of our Dutch bilingual pupils in multiple subjects.

For example, while there are multiple checkpoints present in each area, you can decide to completely forgo them, and instead destroy them for lots of treasure bits.

In fact, with each stage requiring a bit of to and froing for you to work out the best route to the exit, you'll find that you manage to activate multiple checkpoints, multiple times, and it is here where you'll then no doubt find yourself placed in the most awkward, unwanted situatioIn fact, with each stage requiring a bit of to and froing for you to work out the best route to the exit, you'll find that you manage to activate multiple checkpoints, multiple times, and it is here where you'll then no doubt find yourself placed in the most awkward, unwanted situatioin the most awkward, unwanted situation.

The Puzzle mode is the standard approach and lets you complete levels in your own time, Time Trial challenges you to reach a level's multiple checkpoints within a given time limit, and Runner grants you one life with which you must reach the level's conclusion with the risk that if you muck up you will have to start over again.

There's multiple checkpoints and a dozen distinct areas in each.

Moreover, I encountered multiple bugs that forced me to restart checkpoints, along with some visual pop - in issues.

There are multiple choice checkpoint quizzes throughout the course in order to make sure you are retaining all the information you will need.