With this panel, we can identify, or rule out,
multiple diseases inherited in Labradors, such as hip dysplasia, ruptured anterior (cranial) cruciate ligament, mast cell tumor, T and B - cell lymphoma, posterior polar cataracts, liver disease, laryngeal paralysis, degenerative myelopathy, epilepsy, tricuspid valve dysplasia and obesity.
Not exact matches
Familial Alzheimer's also affects
multiple generations, as the mutations that cause the
disease are dominantly
inherited and fully penetrant, which means that if a parent has a mutation, he or she has a 50 percent likelihood of passing it on to his or her children.
inherited neurodegenerative disorders, an array of other genetic
diseases, and
multiple cancers of the bone marrow and lymph nodes.
If the approach also works with human cells, it could eventually lead to cell therapies for
diseases like
inherited leukodystrophies — disorders of the brain's white matter — and
multiple sclerosis, as well as spinal cord injuries.
In addition to his other roles at the institute, he is director of the Clinical Molecular Genetics Training Program, an executive faculty member of the Joint National Institutes of Health - Johns Hopkins University Genetic Counseling Training Program, and the project officer for the Center for
Inherited Disease Research in Baltimore, a research center that analyzes common disorders caused by the actions of
multiple genes and interactions with the environment.
For such complex hereditary
diseases, and dysplasia appears to be one, understanding the pattern of inheritance and making an educated prediction of the likelihood that a puppy will
inherit the
disease depends on testing
multiple relatives of the sire and dam for symptoms.
When clinically normal dogs produce affected offspring, it strongly suggests the
disease is
inherited as a simple recessive (or potentially a polygenic —
multiple gene) trait, and both parents carry one «bad» copy of the gene causing the
disease.
Today we find ourselves faced with
multiple independently
inherited eye
diseases.
We have received reports of
multiple cases of this
disease in families, indicating that it may be
inherited.
It should be noted that many breeds of dog are known to carry
multiple forms of
inherited retinal
disease and the DNA test will not replace the need to remain vigilant for other forms of
inherited eye
disease in the breed.