Sentences with phrase «multiple gene combinations»

This type of disease is labeled polygenic, meaning that it requires multiple gene combinations for expression.

It appears that the synergistic effect of some multiple gene combinations, including Lr2BS, enhances leaf rust resistance.

Not exact matches

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

Fifty - four per cent were single gene mutations, and the other 13 per cent were polygenic DNA variants, meaning they were a combination of multiple bad genes inherited together.

One difficulty in studying the genetics of common mental illnesses is that they are generally caused by environmental factors in combination with multiple gene variants, any one of which usually could not by itself cause disease.

Professor Siddiqui and his team identified multiple biological «micro-clusters» which means that there are different combinations of active genes in each of the reported subtypes of asthma.

This system could be used in combination with hundreds of existing mouse strains that have been engineered to express known cancer genes, allowing researchers to study more thoroughly the interactions of multiple genes.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

For example, during T - cell development genes encoding the TRB molecules are assembled from multiple polymorphic gene segments that undergo rearrangements and selection, generating Vb — Db — Jb combinations that are unique in both length and sequence.

Here we show that pneumococcal lineages from multiple populations each have a distinct combination of intermediate - frequency genes.

In most cases multiple loci will work together so several different genes can be used in combination to produce a color.

A considerable genetic heterogeneity is expected within and among studies, as different combinations of the various alleles of the multiple genes and epistatic gene interactions may produce similar phenotypes.