Sentences with phrase «multiple gene modifications»

We also demonstrate the feasibility of Cas9 / gRNA - mediated multiple gene modifications in primary cells.

Not exact matches

Therefore, applications that require simultaneous modification of all alleles of a gene, or which require modifying multiple genes simultaneously in the same cell, are more appropriate for a CRISPR - based approach.

Also relevant are studies of the upstream mechanisms that regulate levels and function of those gene products, for example: how a transcription factor regulates multiple targets or how factors can regulate translation or post-translational modification of multiple proteins.

Disruption of the gene leads to the development of cataracts via multiple pathways, including the down - regulation or loss of post-translational modification of different crystallin proteins [102].