Sentences with phrase «multiple genes each affect»

Researchers have documented many cases in which multiple genes each affect a trait a little bit.

Not exact matches

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

George Daley of Harvard Medical School said on December 1 that he and his team have seen multiple patients affected by NEMO deficiency syndrome, a disorder where an inherited faulty gene results in a weak immune system and leaves patients prone to serious infections.

The new work, published today in Cell Reports, finds that the protein ADR - 1 binds to messenger ribonucleic acid, or mRNA, and then enhances RNA editing, a process that allows a gene to be present as multiple mRNAs that can then each affect gene expression differently.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

«Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

«This tells us that the NuRD complex is very influential — not only does it affect the activity of genes directly, it also controls other regulators of multiple genes,» Bonni said.

Cystic fibrosis may not be the most likely candidate for gene therapy, however, because the disease affects multiple organ systems.

Compounded by the fact that a single variant might affect multiple transcripts / genes, the number of observed human coding variants exceeds 22 million.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

This implicates putative master regulator genes in which multiple independent stop codon mutations have convergently led to culture adaptation, affecting most laboratory lines of P. falciparum.

There are multiple factors in your diet, environment and lifestyle that affect your genes and how you age.

Through multiple pathways, these bacteria affect our metabolism, our digestive tract, our immune system, and even our genes, cuing our bodies toward better health and permanent weight loss.

Multiple studies have found parallels in brain structure and even identified specific gene analogues when comparing affected humans and canines.

When clinically normal dogs produce affected offspring, it strongly suggests the disease is inherited as a simple recessive (or potentially a polygenic — multiple gene) trait, and both parents carry one «bad» copy of the gene causing the disease.