Sentences with phrase «multiple genes involved»

Modes of inheritance for these diseases are not fully known and are likely to be complex, with multiple genes involved.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

«There are probably multiple genes involved, each with a fairly low effect,» he says.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.

Not exact matches

«Many diseases, especially complex diseases, involve multiple genes, and this system could be used therapeutically to target and activate multiple genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student in the Jaenisch lab and co-author of the Cell Research paper.

«Fascinating genetic studies had been done on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature Genetics paper.

Through these multiple discoveries, the Gladstone scientists noticed that the reprogramming process involves many genes and proteins important for cancer biology.

But other genes were probably also involved, because hominid brain expansion took place in multiple stages over 2 million years, says Ajit Varki, a molecular biologist at the University of California, San Diego.

True blue pigment remained elusive, scientists thought, because its origin was complex; multiple genes have been shown to be involved in its generation.

Pinpointing the genetic causes of common diseases is not easy, as multiple genes may be involved with a disease.

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

It's basically a single amino - acid change in a particular gene, although newer varieties are getting a bit fancier and multiple genes may be involved.

«Lots of genes have multiple roles, but the idea here is that this gene may be involved in the coordination of roles in traits important for feeding and obesity.»

While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.

«Yes, there is a set of diseases that occur more frequently in blacks, but they're complex diseases, involving multiple environmental factors and multiple genes too.

«Crohn's disease is a complex disorder with multiple genes and environmental factors involved, which disproportionally affects individuals of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai in New York City.

Caffeine has evolved multiple times among plant species, but no one knows whether these events involved similar genes.

But because many other diseases, from Alzheimer's to multiple sclerosis, also involve myelin gene changes, it's still not clear whether these changes are central to the disease.

«ANKRD55: New gene involved in Multiple Sclerosis discovered.»

To understand the functional role of miR - 7 in CSCs, we first searched its potential target genes that may be involved in stem cell physiology using multiple database including TargetScan, PicTar, miRanda, and SLOAN - Kettering.

Cas9 - expressing mice can dramatically accelerate our understanding of pathological processes that involve multiple genes or mutations, like tumor development.

I continue this line of research as such, and I currently am the principal investigator on multiple projects involving translational studies involving cell or gene therapy -.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Because mental illnesses are complex, often inherited disorders, scientists have assumed that multiple genes are involved in their cause, each contributing a tiny portion to the total risk.

Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.

Here we use multiple gene expression technologies to curate and measure the activity of all the genes involved in the detection of odors and find evidence of many new ones.

Real - time RT - PCR experiments showed that gene expression of multiple factors involved in angiogenesis, neural function, and myelination were increased in the MSC - injected nerves.

Kmiec noted that while some ailments, like sickle cell anemia and Huntington's disease, involve faulty DNA within a single gene, others, like Alzheimer's and heart disease, appear to involve malfunctions in multiple genes where the best option «is not really gene editing, but gene replacement.»

Carcinogenesis is a complex process involving multiple sequential mutations, which occur randomly in the DNA of normal cells over many years, even decades, until finally specific genes are mutated and cell growth becomes out of control resulting in the full neoplastic phenotype and often metastasis.

If multiple genes are involved the numbers might be much higher.

On the genetic side, it presents a complex pattern of inheritance involving multiple genes and groups of genes.

Inherited disorders most commonly can be caused by a gene defect that is either autosomal dominant, autosomal recessive, sex - linked, mitochondrial, or may involve multiple genes (more on this later).

But because multiple genes are involved, scientists have yet to unravel the pattern of inheritance.