Sentences with phrase «multiple mechanisms of action»

Interferons may have multiple mechanisms of action in viral diseases for example modulating cellular and immune functions and impairing virus replication.

These include curcumin's multiple mechanisms of action and side benefits as well as the serious side effects of drugs like Prozac.

Membrane - anchored plakoglobins have multiple mechanisms of action in Wnt signaling.

«Cimetidine is one of the most interesting examples of repurposed drugs in oncology — a drug with an extensive history of pre-clinical and clinical evidence of efficacy in a range of different cancers and with multiple mechanisms of action at work,» says Pantziarka.

Not exact matches

«One Profession, Multiple Careers» is only a year - and - a-half old, and the bottom - up approach used to develop instruments like this usually takes a long time to develop, since its main mechanism of action is persuasion via discussions at conferences and workshops.

«Our research highlights a potentially new mechanism of dinaciclib action, and raises the possibility that this agent could be a useful addition to current multiple myeloma and myeloid leukemia therapies.»

«There are efflux pumps that can export multiple drugs that have different structures and mechanisms of action.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

Quantitative proteomics can also be applied to identify major candidates of proteins targets and mechanism of action by specifically designed experiments using multiple drug / compounds in addition to that / those of interest and probing drug / compound - specific proteome responses to a treatment.

Her project will determine whether the molecules affect aging in multiple invertebrate species and elucidate their mechanisms of action.

Because of its novel mechanism of action, AST - OPC1 could also potentially benefit patients with other neurological disorders associated with de-myelination, such as multiple sclerosis and white matter stroke.

iTeos has a broad pipeline focused on multiple complementary mechanisms of action including small molecules targeting IDO1, A2A, and STING as well as antibodies directed to TIGIT and Galectin 3.

Multiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and / or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antMultiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and / or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antmultiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

To minimize potential toxic effects, care should be taken to avoid using multiple products with the same mechanism of action (e.g., neonicotinoids, such as imidacloprid and dinotefuran, share similar modes of action).