That is, they contained
multiple populations of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing tumors to survive drug therapy.
Not exact matches
In the clearest possible case, the ANT - OAR
cell would differ from a zygote on all
of the parameters noted above: The ANT - OAR
cell would have a pattern
of gene expression that is clearly distinct from a zygote; it would generate a homogeneous
population of cells rather than
multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.
This finding comes as a surprise, considering that the average migration speed
of the larger
cell population does not change through
multiple cycles.
This murine model system offers a superior source
of immortalized
cell populations as many
of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many
cells, different sites
of gene integration,
multiple copy number; Ref.
In other words, a single
population of MDS
cells underwent
multiple rounds
of mutation and selection, giving rise to
multiple subpopulations present in full - blow secondary AML.
No Association Between Response Rates and Survival in Newly Diagnosed
Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who
Multiple Myeloma: Results
of a recent meta - regression analysis
of 63 randomized clinical trials out
of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed
multiple myeloma in populations of patients who received stem cell transplant and those who
multiple myeloma in
populations of patients who received stem
cell transplant and those who did not.
More than half
of mammalian genes generate
multiple messenger RNA isoforms that differ in their 3 ′ untranslated regions (3 ′ UTRs) and therefore in regulatory sequences, often associated with
cell proliferation and cancer; however, the mechanisms coordinating alternative 3 ′ - UTR processing for specific mRNA
populations remain poorly defined.
The overall picture is compatible with a model
of multiple states
of pluripotency within a highly dynamic
cell population.