Recent approval from the U.S. Food and Drug Administration to begin clinical studies was based on compelling activity upon IACS - 10759 treatment in
multiple preclinical models of AML.
In
multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapy.
Not exact matches
«In 2015 our research team showed that blocking a different protein in the NOD2 pathway could halt inflammation, and was able to halt the progression of
multiple sclerosis in a
preclinical model.
Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use
multiple animal
models in the
preclinical research stage, because one animal
model may not fully recapitulate the human disease.
Other humanized mice have no spontaneous phenotype and can be combined with either genetic spontaneous or inducible
models of chronic inflammatory diseases yielding
preclinical efficacy evaluation platforms for Rheumatoid Arthritis, Intestinal Inflammation, Psoriasis and
Multiple Sclerosis.
iTeos is now developing EOS200271 which is a synthetic, small molecule inhibitor of indoleamine 2,3 - dioxygenase (IDO1), which has demonstrated the same anti-tumour activity in
multiple preclinical tumour
models in combination with immune checkpoint inhibitors as competitors, but also has demonstrated superior brain penetration.
Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct
preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in
multiple mouse tumor
models.
EOS200271 has demonstrated anti-tumor activity in
multiple preclinical tumor
models in monotherapy and in combination with immune checkpoint inhibitors.
«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «
Preclinical models have demonstrated a critical role for autophagy in
multiple cancer types.»
Here we report the development and
preclinical characterization of a novel CD123 - targeting ADC, IMGN632, which utilizes a highly potent DNA - alkylating payload, resulting in an ADC with robust
preclinical activity in
multiple models of AML.