Sentences with phrase «multiple randomized studies»

An analysis of more than 600 class I (procedure / treatment should be performed / administered) American College of Cardiology / American Heart Association guideline recommendations published or revised since 1998 finds that about 80 percent were retained at the time of the next guideline revision, and that recommendations not supported by multiple randomized studies were more likely to be downgraded, reversed, or omitted, according to a study in the May 28 issue of JAMA.

Among recommendations with available information on level of evidence, 90.5 percent of recommendations supported by multiple randomized studies were retained, vs 81.0 percent of recommendations supported by 1 randomized trial or observational data and 73.7 percent of recommendations supported by opinion.

Not exact matches

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

The study was the first ASD research to use a sequential multiple assignment randomized trial, or SMART, design.

Ideally, Hirsch and Morello said they would like to conduct a larger, randomized study with multiple clinics and multiple health systems over a longer time period.

The randomized, double - blind, placebo - controlled study will evaluate the safety and tolerability of multiple doses of NPT088, as well as pharmacokinetics, immunogenicity and pharmacodynamic characteristics, as measured by Aβ and tau PET imaging.

Not only is vitamin D deficiency a risk factor for osteoporosis, but epidemiological studies and randomized, controlled trials suggest a correlation with diseases including cardiovascular disease, some cancers, respiratory infections, and multiple sclerosis.

In a larger study, adults with multiple risk factors and LDL choles - terol concentrations above 4.14 mmol / L or between 3.37 and 4.14 mmol / L were randomized to one of seven groups to receive either oatmeal or oat bran at various levels or a placebo control (Davidson et al., 1991).

IES is also sponsoring a national effort (the What Works Clearinghouse) to survey the research literature and summarize the evidence on multiple education - related topics, giving the greatest weight to rigorous studies based on randomized trials.

Unlike the majority of existing research in the human - animal interaction field, this rigorously designed pilot study took place at multiple sites, and incorporated a randomized control cohort and validated instruments.

The clinical trial comes on the heels of a breakthrough Zoetis - American Humane Association pilot study — Canines and Childhood Cancer: Measuring the Effects of Animal - Assisted Therapy for Pediatric Oncology Patients, Their Parents and Therapy Dogs — that confirmed the feasibility of conducting a randomized control trial using AAT in multiple settings.

Large long term longitudinal studies in which children with GD and their families are randomized to treatment with various therapeutic modalities and assessed across multiple measures of physical and social emotional health are desperately needed and should have been launched long ago.

The study involved a sets of schools randomized within 3 U.S. locations; the longitudinal analysis involved children of multiple ethnicities who remained in the same intervention or control schools for Grades 1, 2, and 3.