Mutations in human PARK2 cause the most common form of familial Parkinson's disease, autosomal recessive juvenile parkinsonism, which has clinical and pathological similarities to canine
multiple system degeneration.
The Mutation of the SERAC1 gene associated with canine
multiple system degeneration has been identified in Kerry blue terriers, although its overall frequency in this breed is unknown.
Johnson GS, Mhlanga - Mutangadura T, Morava E, Kozicz T, Taylor JF, O'Brien DP, Schnabel RD. Canine
Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract].
Genetic testing of the SERAC1 gene in Kerry blue terriers will reliably determine whether a dog is a genetic Carrier of canine
multiple system degeneration (Kerry blue terrier).
Canine
multiple system degeneration (CMSD), is a progressive inherited autosomal recessive neurological movement disorder affecting Chinese Crested dogs, also called pure cerebellar ataxia (PNA) in Kerry Blue Terrier dogs.
Not exact matches
While axonal
degeneration appears to be a major culprit in diseases like
multiple sclerosis, it also paradoxically plays an important role in properly wiring the nervous
systems of developing embryos.
Immune
system degeneration, neurological
system disorders, cancer, arthritis, diabetes,
multiple sclerosis, obesity, cardiovascular disease, kidney failure, and even reproductive
system disorders, the list goes on and on.