Sentences with phrase «multiple transcription factors»

Activation of these pathways further leads to the activation of multiple transcription factors, pro- and antiapoptotic proteins, cell cycle check point proteins, etc. [4, 6, 8].

Not exact matches

When those same transcription factors land on another part of the code, the risk of multiple sclerosis appears to rise.

One encodes retinoid - related orphan receptor alpha (RORα), a transcription factor that itself regulates multiple other genes.

After much experimentation with multiple combinations, the researchers found that adding two more signals to the mix — transcription factors called ISL1 and LHX3 — turned the skin cells into spinal cord motor neurons in about 30 days.

The overall aim of this study was to determine if pluripotent cells overexpressing these transcription factors could be intentionally driven toward retinal progenitors that differentiate into multiple retinal cell classes and form a functional retina.

Ellen V. Rothenberg and Susan B. Ward report that the interleukin - 2 (IL - 2) transcriptional apparatus integrates multiple types of biochemical information in determining whether or not the gene will be expressed, using multiple diverse transcription factors that are each optimally activated or inhibited by different signaling pathways.

XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].

A major aspect of this process is the production of multiple angiogenic cytokines and growth factors in response to hypoxia / ischemia, which is mediated by the transcription factor HIF - 1 (hypoxia - inducible factor 1).

Additionally, ERK1 / 2 and AKT are known to cross talk with multiple substrates including several kinases, transcription factors, etc. which increase the complexity of the signaling network.

What they found was that there were two populations of transcription factors — a diffuse set of smaller molecules and distinct, larger clusters made up of multiple Mig1p's.

In the current study, the researchers found that EBNA2 and its related transcription factors activate some of the human genes associated with the risk for lupus and several other autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, juvenile idiopathic arthritis and celiac disease.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Working in Brennan's lab, she took on the challenge of understanding how a transcription factor in soil bacteria regulates a transporter of multiple drugs.

Also relevant are studies of the upstream mechanisms that regulate levels and function of those gene products, for example: how a transcription factor regulates multiple targets or how factors can regulate translation or post-translational modification of multiple proteins.

Thus, depending on arrangements of the octamer motif, and presence of DNA motifs for additional transcription factors, Oct4 can form heterodimers with multiple partners or homodimers in one of several unique conformations [17].

«There are multiple interactive pathways and molecular mechanisms by which CR (calorie restriction) and IF (intermittent fasting) benefit neurons including those involving insulin - like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator - activated receptors.