Sentences with phrase «multiple tumors in»

A disease affecting middle aged dogs, malignant histiocytosis produces multiple tumors in the skin on the limbs or trunk.

More often than not, a single dog will have multiple tumors in its 10 mammary glands, each at a different stage of progression.

It is important to recognize that multiple tumors in the liver are not always cancers.

It's an insidious disease that can manifest as a solitary or multiple tumors in the skin or can also affect internal organs.

Often, metastasized tumor cells spread more rapidly than primary tumor cells and it is not uncommon to develop multiple tumors in several areas of the brain.

The researchers fed capsaicin to mice genetically prone to developing multiple tumors in the gastrointestinal tract.

Not exact matches

«Opdivo has become a foundational treatment that is transforming cancer care across multiple tumor types,» chief executive Giovanni Caforio said in a statement.

Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.

As she was speaking, saying words like «multiple tumors on his liver,» «possible liver cancer» and «tumor markers,» I felt weak in the knees.

In December, Pope Francis announced that Mother Teresa would be declared a saint after recognizing a second miracle attributed to her: the healing of a Brazilian man with multiple brain tumors after loved ones prayed to her.

Given the results of a a new study reported in the British medical journal, The Lancet4 that children and young adults scanned multiple times by CT have a small increased risk of leukemia and brain tumors in the decade following their first scan, parents should make sure a CT scan is really necessary in treatment of their child after head injury.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Health.

He is now fashioning the lab's multidots — tiny crystalline beads encapsulated in a special coating — into an actual product to detect multiple biomarkers on tumor cells.

«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.

In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumorIn recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumorin the tissue invasion and metastasis of multiple tumors.

The investigators utilized a targeting method called RNA interference (RNAi) which, when delivered via these natural nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.

This gene is known to be highly active in multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety of tumors.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

In other words, regardless of surgery timing, patients who require higher risk procedures, such as a major liver resection due to the presence of larger or multiple metastatic tumors or high - risk colorectal resections, have poorer outcomes than those who underwent more minor surgery.

Multiple myeloma is a cancer of plasma cells in the blood that causes tumor growths in bone marrow.

ICELL8 can isolate up to 1,800 single cells, ranging from 5 μm — 100 μm in size on a single chip, including cells from solid tumors, brain cells, pulmonary airway cells, and multiple cell lines.

Based on their results, Lu and her colleagues argue that the best strategy in such cases might be to use drug combinations that target multiple, parallel pathways involved in tumor development and maintenance.

In this latest study, researchers were able to demonstrate the ability of the nanosensor to illuminate tumor tissue in multiple mouse modelIn this latest study, researchers were able to demonstrate the ability of the nanosensor to illuminate tumor tissue in multiple mouse modelin multiple mouse models.

«These tumors are genetically very complex, and we demonstrated this by showing just the sheer volume of copy number changes, and that there are multiple clones in a single metastases tumor, and changes in metabolism that reflects the tumor's ability to adapt.»

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medicalmultiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard MedicalMultiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

People were reporting it in brain tumors, in Alzheimer's disease, in multiple sclerosis.

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

«Therapy shrinks tumors in patients with multiple myeloma.»

Or it could identify the primary tumor in situations where multiple lesions are present and it is ambiguous which one is responsible for seeding metastases.»

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

In this case, the patient was able to go home the day after the successful removal of multiple brain tumors.»

MRI technology was used to identify and locate a probably tumor (outlined in yellow) during a targeted prostate biopsy for a patient who had previously had multiple negative biopsies but had persistently high PSA levels.

«Having these personalized laboratory models, which we can make in a matter of weeks, will let us test multiple different drugs on the tumor and help us bring precision medicine to individuals with bladder cancer.»

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumor type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

BETs have been fast - tracked into clinical trials and have shown impressive slowing of tumor growth in multiple cancer types.

Such skills could translate well in medicine, for example, where physicians compare multiple diagnostic x-rays over time to identify tumors or growths.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

It is generally believed that a series of mutations in multiple genes are needed for cancer cells to become metastatic; however, recent cancer stem cell theory, which still remains as a hypothesis, predicts that metastatic tumor cells are, by definition, cancer stem cells and that these cells may exist in tumor mass even at an early stage.

In their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patientIn their search for novel, tumor - specific therapies that could target multiple brain metastases without damaging adjacent tissues, the research team first developed a mouse model that more closely mimics what is seen in patientin patients.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

The Ludwig Center at the University of Chicago --- under the direction of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair of the Department of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute at the University of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary tumor to multiple distant sites.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Career Goals: I plan to pursue a career in scientific research focused in NKT cells which assist in prevention of autoimmune diseases such as diabetes, multiple sclerosis and tumors.

As if that had not been complicated enough already, it has been discovered that even the very same tumor can harbor multiple different stem cell populations in its midst!

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

Yongwon Choi, with Ralph Steinman and others, identifies a new tumor necrosis factor family member TRANCE (later called RANKL), [i] and subsequently demonstrates its role in the immune and bone system, and also in bone - residing cancers such as multiple myelomas.

These cells are cancerous yet have properties of stem cells: self - renewal and the ability to differentiate into multiple cell types that occurs in tumors.