Cambridge, Mass. — February 19, 2014 — A new bioprinting method developed at the Harvard School of Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University creates intricately patterned, three - dimensional tissue constructs with
multiple types of cells and tiny blood vessels.
But that production stops after a meal, when insulin is released by the pancreas and performs its main task of removing sugar from the blood and shepherding the glucose to
multiple types of cells that absorb it for energy.
Not exact matches
To build nationwide 5G, they either have to kick current customers off LTE, which would take years, or use a
type of spectrum (millimeter wave) that can only carry a signal 2,000 feet from a
cell site — versus
multiple miles for other spectrum — making it nearly impossible for either
of them to create a truly nationwide 5G network quickly.
In the clearest possible case, the ANT - OAR
cell would differ from a zygote on all
of the parameters noted above: The ANT - OAR
cell would have a pattern
of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population
of cells rather than
multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.
It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression
of multiple sclerosis, it has the ability to regenerate brain
cells after a stroke, it has the ability to cross the blood - brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque from the brain (which studies haves linked to Alzheimer's), it may help to prevent certain
types of cancer, and studies have shown that it inhibits cancer
cell growth and metastases (meaning it keeps cancer from spreading).
Habanero, jalapeno, Scotch bonnet — these hot but yummy
types of the actual capsicum frutescens possess
multiple health advantages — such as the capability to drive prostate cancer
cells to kill themselves.
Breech Twins and higher order
multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy
Type 1 diabetes
Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle
Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because
of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
(borrowed from Dr Kitty) Breech Twins and higher order
multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy
Type 1 diabetes
Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle
Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because
of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
One way to get many
types of cells or proteins from the same genetic starting material is by mixing and matching different parts
of one gene to produce
multiple gene readouts, a phenomenon known as alternative splicing.
The olfactory system comprises six million to 10 million receptor
cells (
of which there are nearly 400 different
types) and links to
multiple brain structures and neural pathways, including those involved in memory, emotion and movement.
Whether investigating fat
cells, immunotherapy or use
of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a select number
of patients suffering from three
types of cancers, including
multiple myeloma, approaches beyond attacking cancer
cells are needed in the fight against many cancers.
Rewinding skin
cells back to their origins in the womb could provide a powerful new vaccine against
multiple types of cancer.
But like the medieval alchemists, today's cloning and stem
cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a
cell's differentiation as smoothly as nature's program
of development does every time fertilized egg gives rise to the
multiple cell types that make up a live baby.
One
type of stem
cell can produce
multiple types of nerve
cells at different stages
of the brain's development.
In the case
of type 1 diabetes, it destroys the insulin - producing
cells in the pancreas, and in
multiple sclerosis it strikes the central nervous system.
Though a range
of developmental scenarios in
multiple brain regions is surely at work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set
of cells — among hundreds
of cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.
When you're using certain tissue
types that can't replicate
multiple times outside
of the body — liver and nerve
cells, for example — «that's where stem
cells are most relevant.»
Researchers at MIT have now shown that they can use a new
type of measurement to predict how drugs will affect cancer
cells taken from
multiple - myeloma patients.
Though most
of these proteins are present in
multiple root
cell types, the researchers found, their statistical models and experiments in living plants suggest the combined effect is to activate the Short - root master switch in some
cells but not others.
The device, part
of the Lab's iCHIP (in - vitro Chip - Based Human Investigational Platform) project, simulates the central nervous system by recording neural activity from
multiple brain
cell types deposited and grown onto microelectrode arrays.
Dor's own group reports this week that its technique for tracing the origin
of circulating DNA detected the expected
type of cell death in people with pancreatic cancer,
type 1 diabetes,
multiple sclerosis, and brain injuries.
«This study focused on the development
of the neocortex, but we aim to analyze
multiple brain regions and developmental stages to achieve a more comprehensive atlas
of cell types in the developing human brain,» Kriegstein said.
Using different
types of perovskites across
multiple layers could allow solar
cells to more effectively absorb a broader range
of photons.
The 5E5 antibody recognized
multiple types of cancer
cells, including leukemia, ovarian, breast, and pancreatic cancer
cells, but not normal tissues.
Multiple myeloma is a blood cancer that forms in a
type of white blood
cell called a plasma
cell.
Theoretically, such stem
cells can form any
of the body's
cell types and could be used in new treatments for Parkinson's disease, diabetes,
multiple sclerosis, cardiac disease, and spinal cord injuries.
The work contradicts previous studies that found that
multiple types of unidentified supporting
cells transform into hair
cells when Notch signaling is blocked.
Hsp90 inhibitors are among several innovative new
types of treatment designed to attack cancer indirectly, by destabilising
multiple different proteins required for the growth and survival
of cancer
cells.
«ADRCs consist
of multiple cell types with
multiple potential benefits,» said Timothy D. Henry, MD, MSCAI, director, division
of cardiology at the Cedars - Sinai Heart Institute and the study's lead investigator.
Cancer
cells resemble stem
cells not because they can turn into other
cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through
multiple layers
of stop signs and barricades and just keep on multiplying.
«Because Th17
cells have been linked to a number
of autoimmune diseases, including
multiple sclerosis, we thought our compound might inhibit Th17
cells in
type 1 diabetes and possibly interfere with disease progression,» said Solt.
What is there — a spinal cord, all major regions
of the brain,
multiple cell types, signaling circuitry and even a retina — has the potential to dramatically accelerate the pace
of neuroscience research, said Anand, also a professor
of neuroscience.
Taste buds contain several
types of chemosensory
cells and are innervated by
multiple nerve fibers.
Oligodendrocytes, a
type of brain
cell that plays a crucial role in diseases such as
multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet / SciLifeLab and Gonçalo Castelo - Branco, Karolinska Institutet.
Because most immune
cells typically can't get into the brain, microglia are adapted to perform
multiple functions that are normally handled by several different
types of immune
cells.
These
cells are cancerous yet have properties
of stem
cells: self - renewal and the ability to differentiate into
multiple cell types that occurs in tumors.
Low - serum conditions for expansion culture
of multiple cell types.
The SDF - 1 / CXCR4 interaction stimulates tyrosine phosphorylation
of CXCR4, followed by the activation
of multiple G protein - dependent signaling pathways, which may be different among
cell types.
New studies in mice have shown that immature stem
cells that proliferate to form brain tissues can function for at least a year — most
of the life span
of a mouse — and give rise to
multiple types of...
Myeloma — also referred to as
multiple myeloma or plasma
cell myeloma — is a cancer that originates in plasma
cells, a
type of white blood
cell that makes antibodies.
Current explorations into the molecular underpinnings
of cell circuitry are leveraging
multiple data
types including expression profiling and epigenetic analysis leveraging RNA - seq and CHiP - Seq coupled with molecular markers and cellular phenotypes.
Therefore, successful recovery from blindness due to injury or disease will require the functional replacement
of multiple retinal
cell types.
Blastic plasmacytoid dendritic
cell neoplasm (BPDCN) is a very aggressive
type of cancer with
multiple manifestations including skin lesions, abnormal
cell counts and central nervous system (CNS) disease involvement.
LIGHT is another member
of the TNF family that can be induced on
multiple cell types including T
cells and dendritic
cells.
Recent studies have described a subpopulation
of cancer
cells within tumors termed «cancer stem
cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into
multiple cancer
cell types [1 — 7].
Several
types of targeted therapy may be used to treat
multiple myeloma and other plasma
cell neoplasms.
Intercellular adhesion molecule - 1 expression is required on
multiple cell types for the development
of experimental autoimmune encephalomyelitis.
We compared the
cell - fractions
of pre - and post-mortem samples globally using the Anderson — Darling test53 and by
cell -
type obtaining a p - value using the two - sided Wilcoxon Rank - Sum test54, adjusted to
multiple - testing by Benjamini — Hochberg method44.
«The best case scenario is that from this one very accessible and highly proliferative source
of stem
cells, we will be able to obtain
multiple different
cell types that can be used for a broad range
of applications in regenerative medicine,» he said.
As the effects
of these tools are likely
cell type - and context - dependent, it may make sense to try
multiple CRISPR tools when setting up your experimental system.