Sentences with phrase «muscle cell markers»

«Eighty - two percent of the smooth muscle cells within advanced atherosclerotic lesions can not be identified using the typical methodology since the lesion cells down - regulate smooth muscle cell markers.

Not exact matches

They injected this handcrafted virus into rats and found that the marker gene was indeed active only in smooth muscle cells.

But in the 1 September issue of the Journal of Clinical Investigation, cardiologist Michael Parmacek and his colleagues at the University of Chicago describe how they deleted two genes from the common cold virus to make it unable to cause any sniffling or fever, then replaced them with a marker gene that turns out an easily detected protein and the SM22 promoter, which turns on expression of genes in smooth muscle cells that surround arteries.

In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome — DNA, epigenetic markers and RNA — during the development, maturation and disease of human cardiac muscle cells.

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

Once they were able to isolate skeletal muscle cells using the newly identified surface markers, the research team matured those cells in the lab to create dystrophin - producing muscle fibers.

Using the ERBB3 and NGFR surface markers, the skeletal muscle cells were isolated and then injected into mice at the same time a TGF Beta inhibitor was administered.

Skeletal muscle cells isolated using the ERBB3 and NGFR surface markers (right) restore human dystrophin (green) after transplantation significantly greater than previous methods (left).

The answer was yes: They found cells with markers from all three major body cell types, called germ layers: ectoderm (such as nerve cells), mesoderm (muscle and blood vessel cells), and endoderm (kidney cells).

In order to locate all gene switches, the Freiburg research team used modern sequencing methods to examine the entire genome - DNA, epigenetic markers and RNA - during the development, maturation and disease of human cardiac muscle cells.

«But the desired cells often lack a readily accessible surface marker, or that marker is not specific enough, as is the case for cardiac muscle cells.

Red represents the cardiac muscle marker troponin, and green is cadherin, which helps cells stick to each other.

In fact, it turned out that these cells expressed markers characteristic of brain pericytes, such as PDGF receptor beta, smooth muscle actin, NG2 and also CD146 not depicted here.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Infiltrating cells in the myocardium and skeletal muscle were positive for the T - cell marker CD3 or the macrophage marker CD68.

Whilst the supplements did not affect maximal oxygen uptake or the results of a 20 metre shuttle test, the results showed that markers for the production of new muscle mitochondria — the power supply for cells — increased only in the group without supplements.

MyoD is normally only expressed in skeletal muscle, and it was later found to be a transcription factor involved in the differentiation of muscle cells and also a very early marker of muscle cell fate commitment.

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].

Compression stockings improved all markers of recovery except for creatine kinase (a marker of muscle cell damage).