Using the natural human development process as a guide, the researchers developed ways to mature
muscle cells in the laboratory to create muscle fibers that restore dystrophin, the protein that is missing in the muscles of boys with Duchenne.
Not exact matches
Future Meat Technologies is working to commercialize a manufacturing technology for fat and
muscle cells that was first developed
in the
laboratories of the Hebrew University of Jerusalem.
Drugs that enhance a process called oxidative stress were found to kill rhabdomyosarcoma tumor
cells growing
in the
laboratory and possibly bolstered the effectiveness of chemotherapy against this aggressive tumor of
muscle and other soft tissue.
«It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human
muscle from pluripotent stem
cells,» said Lingjun Rao, a postdoctoral researcher
in Bursac's
laboratory and first author of the study.
Dr. Espen Spangenburg, associate professor of kinesiology, and his
laboratory team are the first to identify that the BRCA1 protein is expressed
in the skeletal
muscle of both mice and humans, and that it plays a key role
in fat storage, insulin response and mitochondrial function
in skeletal
muscle cells.
In a
laboratory dish — and, presumably, also inside the body — these
cells readily multiply and give rise to various structural
cells, such as fat,
muscle, bone, tendon, ligament and cartilage.
They have generated excitement over the past few decades because scientists can study them
in the
laboratory to discover the genetic switches that control the development of specialized tissues
in the embryo and fetus, and also because of their potential to replace body tissues that have broken down, such as pancreatic
cells in those with diabetes or heart
muscle cells in those with congestive heart failure.
In the case of the Circulation paper, which reported a surprisingly high turnover rate for muscle cells in the adult heart, Leri and Anversa say that Kajstura apparently altered, without their knowledge, data from mass spectrometry experiments performed at Lawrence Livermore National Laboratory (LLNL) in Californi
In the case of the Circulation paper, which reported a surprisingly high turnover rate for
muscle cells in the adult heart, Leri and Anversa say that Kajstura apparently altered, without their knowledge, data from mass spectrometry experiments performed at Lawrence Livermore National Laboratory (LLNL) in Californi
in the adult heart, Leri and Anversa say that Kajstura apparently altered, without their knowledge, data from mass spectrometry experiments performed at Lawrence Livermore National
Laboratory (LLNL)
in Californi
in California.
«This is the first study to demonstrate that functional
muscle cells can be created
in a
laboratory and restore dystrophin
in animal models of Duchenne using the human development process as a guide.»
By carefully guiding the
cells» choices at each fork
in the road, Loh and Chen were able to generate bone
cell precursors that formed human bone when transplanted into
laboratory mice and beating heart
muscle cells, as well as 10 other mesodermal - derived
cell lineages.
An MDI Biological
Laboratory assistant professor says he has identified processes that underlie how heart tissue regenerates, which
in turn holds out hope of finding new drugs that can help the body grow
muscle cells and get rid of scar tissue.
In recent years, our
laboratory has focused much effort on understanding the molecular and cellular mechanisms regulating
muscle cell fusion.
Working
in dystrophic mice while searching for a cure for Duchenne muscular dystrophy (DMD), Dr. Huard's
laboratory team first identified a unique population of
muscle - derived stem
cells with the ability to repair
muscle 8 years ago.
In a study using human muscle tissue, scientists in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cell
In a study using human
muscle tissue, scientists
in Children's Stem Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage cell
in Children's Stem
Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem cells taken from blood vessels (known as myoendothelial cells) that are easily isolated using cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ce
Cell Research Center - led by Johnny Huard, PhD, and Bruno Péault, PhD - isolated and characterized stem
cells taken from blood vessels (known as myoendothelial
cells) that are easily isolated using
cell - sorting techniques, proliferate rapidly and can be differentiated in the laboratory into muscle, bone and cartilage ce
cell - sorting techniques, proliferate rapidly and can be differentiated
in the laboratory into muscle, bone and cartilage cell
in the
laboratory into
muscle, bone and cartilage
cells.
Her
laboratory focuses on the roles of the actin cytoskeleton
in cell architecture and physiology
in organs such as
muscle, blood and eyes.
This lag
in energy production tends to occur earlier than changes
in blood
cell production, so the
muscle fatigue and changes
in concentration are likely to be noticeable long before
laboratory testing shows low blood
cell production.