Sentences with phrase «muscle dystrophy»

Acute ablation of autophagy leads to animal death caused by infection, diabetes, and neurodegeneration, as well as muscle dystrophy and reduced fat storage [18].

Inhibitors and activators of fusion, members of various signaling pathways, genes that when mutated, lead to muscle dystrophies in human: there are many surprises within this list of putative modulators of muscle fusion.

Not exact matches

And Crispr - Cas9 isn't even the only type of Crispr out there: On April 12, researchers at the University of Texas Southwestern Medical Center announced they had successfully paired the gene - editing tool with a different kind of enzyme, called Cpf1, to correct mutations associated with the devastating muscle - wasting disorder Duchenne muscular dystrophy.

That appears to be the case with Marathon Pharmaceuticals» deflazacort, a steroid that has now achieved FDA approval for treating the devastating muscle - wasting disorder Duchenne muscular dystrophy (DMD).

MDA Summer Camp provides thousands of kids with muscular dystrophy and related muscle - debilitating diseases «the best week of the year.»

And then there's kids with digestive issues, thyroid or other endocrine problems, severe allergies, mitochondrial disorders, various muscle myopathies or dystrophies, etc, etc..

Toe walking is sometimes the result of cerebral palsy, muscular dystrophy or another generalized disease of nerve and muscle.

This muscle enzyme is very high in children with muscular dystrophy.

An example would be muscular dystrophy, which is a devastating genetic muscle disease.

Drugs that turn on PGC - 1beta could be used to treat muscle - wasting diseases like muscular dystrophy — or to create superathletes.

Children with muscular dystrophy lack the gene required to regulate dystrophin, a protein for muscle growth and stability.

Duchenne muscular dystrophy is caused by problems with the body's ability to produce dystrophin, a long protein chain that binds the interior of a muscle fiber to its surrounding support structure.

These are the muscular dystrophies (among which are Duchenne and Becker); motor neuron diseases (including ALS and SMA); the peripheral nerve disorders (CMT and Friedreich's ataxia); inflammatory myopathies; disorders of the neuromuscular junction; metabolic diseases of muscle as well as other myopathies.

Muscular dystrophies are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement.

«Their muscle tissue looked like that of Duchene's muscular dystrophy [DMD] patients,» Baur said.

Both viruses were used to infect muscle cells in the hind legs of mice that had muscular dystrophy.

This summer Wagers published research [subscription required] showing that when muscle stem cells were transferred into mice with a type of muscular dystrophy, the rodents» muscle function improved.

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

In their research, authors Sajedah M. Hindi, Ph.D., and Ashok Kumar, Ph.D., discovered that removing TRAF6 depletes Pax7, resulting in reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse models.

Kumar and Hindi believe their research ultimately will lead to improved treatments for muscle wasting diseases such as muscular dystrophy, ALS, cancer cachexia, diabetes, heart disease and others.

Researchers who previously showed that a gene therapy treatment could save the lives of dogs with a deadly disease called myotubular myopathy — a type of muscular dystrophy that affects the skeletal muscles — have found that the therapy is long - lasting.

Furthermore, the scientists examined muscle biopsies of patients with congenital muscular dystrophy.

«Scientists slow progression of fatal form of muscular dystrophy: Hope lies in nuclear receptor that regulates muscle.»

«By either skipping a mutation region or precisely repairing a mutation in the gene, CRISPR - Cpf1 - mediated genome editing not only corrects Duchenne muscular dystrophy mutations but also improves muscle contractility and strength,» said co-author Dr. Rhonda Bassel - Duby, Professor of Molecular Biology and Associate Director of the Hamon Center for Regenerative Science and Medicine.

Scientists at the University of Liverpool have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair.

In worms, muscles normally harbor a newly found acetylcholine transporter to help them work, like those shown here, but those with a disease resembling Duchenne muscular dystrophy lack the molecule.

The new technique can also be used to grow muscle cells from iPS cells from patients with neuromuscular diseases like ALS, spinal muscular atrophy and muscular dystrophy.

However, to treat disorders such as muscular dystrophy, muscles all around the body — including the heart — need to be edited.

«When a child's muscles are already withering away from something like Duchenne muscular dystrophy, it would not be ethical to take muscle samples from them and do further damage.

Yin's research also has implications for the treatment of other diseases involving muscle damage, including muscular dystrophy.

Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.

He hopes that one day his technique can be used to help treat patients with muscular dystrophy, in which their bodies attack their own muscle.

The team also showed that they could recover muscle growth and function in mouse models of muscular dystrophy, a disease with a known gene mutation.

Muscular Dystrophy is a hereditary condition marked by weakness and progressive wasting of the muscles, while ALS impacts nerve cells that control voluntary muscle movement.

Fresh insights into how our cells control muscle development could aid understanding of muscular dystrophy and other inherited diseases.

Drugs targeting myostatin could prove a godsend for people with muscle - wasting diseases such as muscular dystrophy.

«Burnt sugar derivative reduces muscle wasting in fly and mouse muscular dystrophy.»

In addition to muscular dystrophy treatment research, similar studies might also be conducted in the future on loss of muscle strength during normal or accelerated aging.

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy.

Chen's group has now expanded the use of mesh - free simulation methods to investigate aging and disorders impacting muscle functions, such as muscular dystrophy.

The study, published in Nature Medicine on November 16, 2015, is the first to show that Duchenne muscular dystrophy directly affects muscle stem cells.

«For nearly 20 years, we've thought that the muscle weakness observed in patients with Duchenne muscular dystrophy is primarily due to problems in their muscle fibres, but our research shows that it is also due to intrinsic defects in the function of their muscle stem cells,» said Dr. Michael Rudnicki, senior author of the study.

Congenital muscular dystrophy (CMD) is a term used for a group of genetic muscle - wasting conditions, in which the symptoms become apparent at an early age.

«I'm not sure if we will ever cure Duchenne muscular dystrophy, but I'm very hopeful that someday in the future, we will have new therapies that correct the ability of muscle stem cells to repair the muscles of afflicted patients and turn this devastating, lethal disease into a chronic but manageable condition.»

Robert Meadowcroft, Chief Executive of Muscular Dystrophy UK, commented: «Early stage research identifying genes for muscle - wasting conditions, such as this, gives us valuable insight into better understanding these complex and rare conditions.

Now a scientist reports that mice engineered to make extra follistatin, which deactivates myostatin, have four times the muscle of regular mice, suggesting a new target for drugs to fight muscle - wasting diseases such as muscular dystrophy.

Antioxidants are widely used by Baby Boomers with muscles that ache from a grueling workout or newborns diagnosed with muscular dystrophy.

Such an understanding is urgently needed, as no treatments are yet available for muscular dystrophies and muscle - wasting disorders,» stated Alessandra Sacco, Ph.D., associate professor in the Development, Aging, and Regeneration Program at SBP and senior author of the study.

Still the study is «an important first step to show that manipulating AMPK - nNOS signaling at least has the potential to help muscle function in muscular dystrophy,» says Michele whose lab at the University of Michigan Cardiovascular Research Center focuses on inherited forms of skeletal and cardiac diseases.

«Manipulating cell signaling for better muscle function in muscular dystrophy.»