Sentences with phrase «muscle stem cell»

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].

Title: Muscle stem cell behaviour is modified by microRNA - 27 regulation of Pax3 expression.

To discover the next steps on the way forward for this exciting breakthrough for muscle stem cell research, stay tuned to the Stem Cells Portal!

AMPKa1 - LDH pathway regulates muscle stem cell self - renewal by controlling metabolic homeostasis

Title: Regulation of skeletal muscle stem cell behaviour by Pax3 and Pax7 Authors: Lagha M, Sato T, Bajard L, Daubas P, Esner M, Montarras D, Relaix F, Buckingham M Date: 2008 Publication Details: Cold Spring Harbor Symposium on Quantitative Biology 2008.

Accordingly, our data suggests that the failure of regenerative myogenesis to keep pace with disease progression in DMD is not due to muscle stem cell exhaustion, but rather is due to a cell - autonomous deficiency in asymmetric division.

Finally, we show that addition of small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.

In the present seminar, I will summarize our findings concerning the role of Srf in myofibers to control muscle mass and I will present recent data identifying Srf as a master regulator of muscle stem cell fusion and demonstrating the implication of F - actin architecture in this process.

The scientists are eager to find these adult muscle stem cell genes.

They also looked for genes not previously studied for having a role in fusing muscle stem cells.

One of the molecular mysteries hindering development of regenerative therapy for muscles is uncovering the precise genetic and molecular processes that cause skeletal muscle stem cells (called myoblasts) to fuse and form the striated muscle fibers that allow movement.

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

Led by researchers at the Cincinnati Children's Hospital Medical Center Heart Institute, the study demonstrates the gene Gm7325 and its protein — which the scientists named «myomerger» — prompt muscle stem cells to fuse and develop skeletal muscles the body needs to move and survive.

«This research enables us to get one step closer to the optimal culture conditions for muscle stem cells.»

This summer Wagers published research [subscription required] showing that when muscle stem cells were transferred into mice with a type of muscular dystrophy, the rodents» muscle function improved.

The investigators found that when LIF - treated muscle stem cells were transplanted to skeletal muscle, they formed two to three times more muscle fibers as control cells did.

Muscle stem cells which help replace damaged muscle tissue produce myoblasts that will either reproduce (proliferate) or form muscle tissue (differentiate).

Under experimental conditions, the researchers then demonstrated that elevated levels of elastase dramatically reduce the survival and operation of muscle stem cells in culture.

First, the cells are grown in defined supplements without animal products such as bovine serum, enhancing the clinical safety for the muscle stem cells.

«But in the future we might be able to use this technique therapeutically, for example to directly target and correct a mutation in muscle stem cells and muscle fibers.»

«These progenitor cells resemble adult muscle stem cells called «satellite cells» that can theoretically grow an entire muscle starting from a single cell.»

Human muscle cells assemble to form aligned, multinucleated (purple) muscle fibers and resident muscle stem cells (white).

«We learned a lot with this animal model, but perhaps the most important finding was what we observed when we transplanted skeletal muscle stem cells,» said Kyba.

The team could isolate muscle stem cells from the male mice before they died and when they transplanted them into muscle - damaged recipient mice, they found that the stem cells were able to regenerate new muscle.

To their surprise, they found that when old and young mice were joined, the muscle stem cells in old mice were revitalized.

«This is crucial because muscle stem cells need to sense their environment to decide whether to produce more stem cells or to form new muscle fibres.

The study, published in Nature Medicine on November 16, 2015, is the first to show that Duchenne muscular dystrophy directly affects muscle stem cells.

«For nearly 20 years, we've thought that the muscle weakness observed in patients with Duchenne muscular dystrophy is primarily due to problems in their muscle fibres, but our research shows that it is also due to intrinsic defects in the function of their muscle stem cells,» said Dr. Michael Rudnicki, senior author of the study.

Muscle stem cells are responsible for muscle repair after normal injuries and exercise.

Without this information, muscle stem cells can not divide properly and can not properly repair damaged muscle.»

«Muscle stem cells that lack dystrophin can not tell which way is up and which way is down,» said Dr. Rudnicki.

But that idea was confusing to many because GDF11 is very similar to the protein myostatin, which prevents muscle stem cells from differentiating into mature muscle — the opposite effect to that seen by Wagers and her team.

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibres.

More than a decade ago, Discover covered the concept of a coffee - maker - like device that could, overnight, turn a few animal muscle stem cells into a nice hunk of meat.

«I'm not sure if we will ever cure Duchenne muscular dystrophy, but I'm very hopeful that someday in the future, we will have new therapies that correct the ability of muscle stem cells to repair the muscles of afflicted patients and turn this devastating, lethal disease into a chronic but manageable condition.»

Experimental approaches such as gene therapy are also being investigated, but Dr. Rudnicki's research suggests that these approaches will have to be modified so that they target muscle stem cells as well as muscle fibres.

The hamburger was grown in Post's lab using bovine skeletal muscle stem cells, collected from a piece of fresh beef.

«Teaching stem cells to build muscle: New research shows young muscle stem cells can improve adult muscle regeneration.»

First, when muscle is damaged by injury or degenerative disease such as muscular dystrophy, muscle stem cells — or satellite cells — need to differentiate into mature muscle cells to repair injured muscles.

Currently, there is no cure to stop or reverse any form of muscle - wasting disorders — only medication and therapy that can slow the process,» said Vittorio Sartorelli, M.D., chief of the Laboratory of Muscle Stem Cells and Gene Regulation and deputy scientific director at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

The technique also creates a sustainable pool of muscle stem cells needed to support multiple rounds of muscle repair.

This process is also important in adult life because muscle stem cells fuse with existing fibers to achieve muscle growth and help regenerate damaged muscles.

«We believe that in obese individuals the muscle stem cells have been reprogrammed, and that this may partly explain why muscle cells in obese people have decreased insulin sensitivity and lower metabolism after they have matured,» says Cajsa Davegårdh.

In a new study, doctoral student Cajsa Davegårdh has studied so - called DNA methylation in muscle stem cells in both obese and non-obese individuals.

To get round this, Wilhelm Roell at the University of Bonn in Germany and his colleagues loaded muscle stem cells with iron oxide nanoparticles to make them magnetic.

«For a stem cell therapy for Duchenne to move forward, we must have a better understanding of the cells we are generating from human pluripotent stem cells compared to the muscle stem cells found naturally in the human body and during the development process.»

Baltimore, MD — Scientists working at the Carnegie Institution's Department of Embryology, with colleagues, have overturned previous research that identified critical genes for making muscle stem cells.

What makes the muscle stem cells different after three weeks?

The researchers suggest that since the adult muscle stem cells are only activated when injury occurs (by trauma or exercise), they use a new set of genes from those used during embryonic development, which proceeds without injury.